New GABAergic Interneurons supported by myelin-specific T cells are formed in intact adult spinal cord

被引：66

作者：

Shechter, Ravid ^{[1
]}

Ziv, Yaniv ^{[1
]}

Schwartz, Michal ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

来源：

STEM CELLS | 2007年 / 25卷 / 09期

关键词：

neuroimmune; neural stem cell; autoinummity; stromal-derived factor-1; neural differentiation;

D O I：

10.1634/stemcells.2006-0705

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Neural stem/progenitor cells are known to exist in the intact spinal cord, but the presence of newly formed neurons during adulthood has not been documented there to date. Here, we report the appearance of newly formed neurons under normal physiological conditions. These neurons are immature, express a GABAergic phenotype' and are primarily located in the dorsal part of the spinal cord. This localization appeared to be mediated by stromal-derived factor- 1/CXC-chemokine receptor-4 signaling in the dorsal region. The extent of spinal cord neurogenesis was found to be greatly influenced by immune system integrity and in particular by myelin-specific T cells. These observations provide evidence for in vivo spinal cord neurogenesis under nonpathological conditions and introduce novel mechanisms regulating adult spinal cord plasticity.

引用

收藏

页码：2277 / 2282

页数：6

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