Telomerase regulation in differentiated serum-free mouse embryo cells

被引：0

作者：

Katakura, Y ^{[1
]}

Yamamoto, K ^{[1
]}

Miyake, O ^{[1
]}

Nakata, E ^{[1
]}

Yasuda, T ^{[1
]}

Uehara, N ^{[1
]}

Barnes, DW ^{[1
]}

Shirahata, S ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Genet Resources Technol, Higashi Ku, Fukuoka 81281, Japan

来源：

ANIMAL CELL TECHNOLOGY: BASIC & APPLIED ASPECTS, VOL 9 | 1998年

关键词：

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We developed a non-radioisotopic assay to detect telomerase activity in serum-free mouse embryo cells (SFME cells). Using this assay, telomerase regulation mechanism in differentiated SFME cells was investigated SFME cells treated with 10% serum or with 10 ng/ml of TGF-beta showed astrocytes-like phenotypes and lowered telomerase activity, These results indicate that telomerase activity is down-regulated with the differentiation of SFME cells into astrocytes.

引用

页码：11 / 15

页数：5