The many faces of histone H3K79 methylation

被引：115

作者：

Farooq, Zeenat ^{[1
]}

Banday, Shahid ^{[1
]}

Pandita, Tej K. ^{[2
]}

Altaf, Mohammad ^{[1
]}

机构：

[1] Univ Kashmir, Dept Biotechnol, Chromatin & Epigenet Lab, Jammu 190006, Kashmir, India

[2] Houston Methodist Res Inst, Dept Radiat Oncol, Houston, TX 77030 USA

来源：

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2016年 / 768卷

关键词：

Chromatin; Histone methylation; DNA repair; MIXED-LINEAGE LEUKEMIA; STRAND BREAK REPAIR; DNA-DAMAGE; SACCHAROMYCES-CEREVISIAE; LYSINE METHYLATION; H3; METHYLATION; TRANSCRIPTIONAL ELONGATION; COVALENT MODIFICATIONS; CHROMATIN MODIFICATION; TRYPANOSOMA-BRUCEI;

D O I：

10.1016/j.mrrev.2016.03.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Dot1/DOT1L (disruptor of telomeric silencing-1) is an evolutionarily conserved histone methyltransferase that methylates lysine 79 located within the globular domain of histone H3. Dot1 was initially identified by a genetic screen as a disruptor of telomeric silencing in Saccharomyces cerevisiae; further, it is the only known non-SET domain containing histone methyltransferase. Methylation of H3K79 is involved in the regulation of telomeric silencing, cellular development, cell-cycle checkpoint, DNA repair, and regulation of transcription. hDot1L-mediated H3K79 methylation appears to have a crucial role in transformation as well as disease progression in leukemias involving several oncogenic fusion proteins. This review summarizes the multiple functions of Dot1/hDOT1L in a range of cellular processes. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：46 / 52

页数：7

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