Polymorphisms of the receptor for advanced glycation end products and glyoxalase I and long-term outcome in patients with breast cancer

被引：6
作者：
Tesarova, Petra [1 ,2 ]
Zima, Tomas [2 ,3 ]
Kubena, Ales A. [2 ,3 ]
Kalousova, Marta [2 ,3 ]
机构：
[1] Charles Univ Prague, Fac Med 1, Dept Oncol, U Nemocnice 2, Prague 12808 2, Czech Republic
[2] Gen Univ Hosp, U Nemocnice 2, Prague 12808 2, Czech Republic
[3] Charles Univ Prague, Fac Med 1, Inst Med Biochem & Lab Diagnost, Prague, Czech Republic
来源：
TUMOR BIOLOGY | 2017年 / 39卷 / 07期
关键词：
Breast cancer; receptor for advanced glycation end products; polymorphism; oxidative stress; outcome; GENE POLYMORPHISMS; SOLUBLE RECEPTOR; RAGE; EXPRESSION; CELLS; ASSOCIATION; MORTALITY; PROLIFERATION; AMPLIFICATION; S100A12;
D O I：
10.1177/1010428317702902
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Receptor for advanced glycation end products and glyoxalase I metabolizing advanced glycation end product precursors may play important role in the pathogenesis and progression of cancer. Potential relation between soluble forms of receptor for advanced glycation end products (sRAGE), receptor for advanced glycation end products, glyoxalase I polymorphisms, and long-term outcome (median follow-up of 10.3 years) was studied in 116 patients with breast cancer. Gly82Ser and 2184 A/G RAGE polymorphisms were related to the mortality due to the breast cancer and -419 A/C glyoxalase I polymorphism was related to the overall mortality of the patients suggesting their role not only in the risk of breast cancer but also in the outcome of patients with breast cancer.
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页码：1 / 7
页数：7
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