Pd/C-Mediated Dual C-C Bond Forming Reaction in Water: Synthesis of 2,4-Dialkynylquinoline

被引：4

作者：

Reddy, Ellanki A. ^{[2
,3
]}

Islam, Aminul ^{[3
]}

Mukkanti, K. ^{[2
]}

Venu, Bolla K. ^{[3
]}

Pal, Manojit ^{[1
]}

机构：

[1] Matrix Labs Ltd, R&D Ctr, New Drug Discovery, Jinnaram Mandal 502325, Andra Pradesh, India

[2] JNT Univ, Inst Sci & Technol, Div Chem, Hyderabad 500072, Andhra Pradesh, India

[3] Dr Reddys Labs Ltd, Hyderabad 500049, Andhra Pradesh, India

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2010年 / 21卷 / 09期

关键词：

quinoline; palladium; charcoal; copper; C-C bond; alkyne; COUPLING REACTIONS;

D O I：

10.1590/S0103-50532010000900012

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pd/C facilitated dual C-C bond forming reaction between 2,4-diiodoquinoline and terminal alkynes in water providing a practical and one-step synthesis of 2,4-dialkynylquinolines. A number of related quinoline derivatives were prepared in good to excellent yields using this water-based methodology. The use of other palladium catalysts and solvents was examined and the mechanism of the reaction has been discussed.

引用

页码：1681 / 1687

页数：7

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