The Bermuda Triangle of cocaine-induced neuroadaptations

被引：151

作者：

Wolf, Marina E. ^{[1
]}

机构：

[1] Rosalind Franklin Univ Med & Sci, Dept Neurosci, N Chicago, IL 60064 USA

来源：

TRENDS IN NEUROSCIENCES | 2010年 / 33卷 / 09期

关键词：

CA2+-PERMEABLE AMPA RECEPTORS; EXTENDED DAILY ACCESS; NUCLEUS-ACCUMBENS; BEHAVIORAL SENSITIZATION; SYNAPTIC PLASTICITY; INDUCED REINSTATEMENT; SEEKING BEHAVIOR; SODIUM CURRENTS; UP-REGULATION; GLUTAMATE;

D O I：

10.1016/j.tins.2010.06.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Activation of medium spiny neurons (MSNs) of the nucleus accumbens is critical for goal-directed behaviors including cocaine seeking. Studies in cocaine-experienced rodents have revealed three major categories of neuroadaptations that influence the ability of glutamate inputs to activate MSNs: changes in synaptic AMPA receptor levels, changes in extracellular non-synaptic glutamate levels and changes in MSN intrinsic membrane excitability. Most studies have focused on one of these adaptations. This review will consider the possibility that they are causally related and speculate about how time-dependent changes in their interactions may regulate MSN output during early and late withdrawal from repeated cocaine exposure.

引用

页码：391 / 398

页数：8

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