Pallidal deep brain stimulation in juvenile Huntington's disease: local field potential oscillations and clinical data

被引：9

作者：

Ferrea, Stefano ^{[1
,2
]}

Groiss, Stefan J. ^{[1
,2
]}

Elben, Saskia ^{[1
,2
]}

Hartmann, Christian J. ^{[1
,2
]}

Dunnett, Steve B. ^{[3
]}

Rosser, Anne ^{[3
]}

Saft, Carsten ^{[4
]}

Schnitzler, Alfons ^{[1
,2
]}

Vesper, Jan ^{[5
]}

Wojtecki, Lars ^{[1
,2
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Med Fac, Ctr Movement Disorders & Neuromodulat, Dept Neurol, D-40225 Dusseldorf, Germany

[2] Heinrich Heine Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, Med Fac, Univ Str 1, D-40225 Dusseldorf, Germany

[3] Cardiff Univ, Sch Biosci, Brain Repair Grp, Cardiff CF10 3AT, S Glam, Wales

[4] Ruhr Univ, St Josef Hosp, Dept Neurol, Gudrunstr 56, D-44791 Bochum, Germany

[5] Heinrich Heine Univ Dusseldorf, Med Fac, Dept Stereotact & Funct Neurosur, Moorenstr 5, D-40225 Dusseldorf, Germany

来源：

JOURNAL OF NEUROLOGY | 2018年 / 265卷 / 07期

关键词：

Pallidal deep brain stimulation; Juvenile Huntington's disease; Local field potentials; Intraoperative neurophysiology; GLOBUS-PALLIDUS; SUBTHALAMIC NUCLEUS; PARKINSONS-DISEASE; RATING-SCALE; MOTOR; RELIABILITY; DOPAMINE;

D O I：

10.1007/s00415-018-8880-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recently, therapeutic attempts to control motor choreatic hyperkinesia of Huntington's disease (HD) by means of pallidal deep brain stimulation (Gp-DBS) were successful. With respect to the clinical effects of Gp-DBS in juvenile hypokinetic-rigid HD (jHD; Westphal variant), only one single-case has been reported up to date. Oscillatory patterns of the Gp in jHD are not known. This work aimed to analyse pallidal local field potential oscillations (LFP) in two patients with jHD treated with Gp-DBS. Safety data and clinical scores up to 12 months after DBS-electrode implantation were collected in the framework of a prospective trial (ClinicalTrials.gov; NCT00902889). Intraoperative LFP revealed local alpha and beta oscillations similar to those found in other movement disorders with akinetic rigid and dystonic presentation. Significant motor improvement was not found. There were no treatment-related complications or unresolved long-term adverse events. In spite of similar intraoperative LFP patterns of jHD with those of movement disorders benefitting from DBS, clinical results were not convincing in our patients, so that Gp-DBS in jHD cannot be generally recommended.

引用

页码：1573 / 1579

页数：7

共 31 条

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