Brucella lipopolysaccharide acts as a virulence factor

被引：222
作者：
Lapaque, N
Moriyon, I
Moreno, E
Gorvel, JP
机构：
[1] Univ Mediterranee, CNRS, INSERM, Ctr Immunol, F-13288 Marseille 9, France
[2] Univ Navarra, Dept Microbiol, Pamplona 31008, Spain
[3] Univ Nacl, Escuela Med Vet, PIET, Heredia, Costa Rica
来源：
CURRENT OPINION IN MICROBIOLOGY | 2005年 / 8卷 / 01期
关键词：
D O I：
10.1016/j.mib.2004.12.003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Brucella is a facultative intracellular bacterium responsible for brucellosis. Virulence factors involved in Brucella replication and Brucella's strategies to circumvent the immune response are under investigation. VirB proteins that form the type IV secretion system and that are involved in intracellular replication are considered as one of Brucella's virulence factors. In addition to this secretion system, bacterial outer membrane components have also been described as being implicated in Brucella survival in the host. For example, this bacterium possesses an unconventional non-endotoxic lipopolysaccharide that confers resistance to anti-microbial attacks and modulates the host immune response. These properties make lipopolysaccharide an important virulence factor for Brucella survival and replication in the host.
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页码：60 / 66
页数：7
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