Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus

被引:27
作者
Okan, Gokhan [2 ]
Yaylaci, Serpil [3 ]
Peker, Onder [4 ]
Kaymakoglu, Sabahattin [5 ]
Saruc, Murat [1 ]
机构
[1] Acibadem Bakirkoy Hosp, Gastroenterohepatol Dept, TR-34140 Istanbul, Turkey
[2] Acibadem Bakirkoy Hosp, Dept Dermatol, TR-34140 Istanbul, Turkey
[3] Acibadem Bakirkoy Hosp, Dept Emergency, TR-34140 Istanbul, Turkey
[4] Acibadem Bakirkoy Hosp, Dept Pathol, TR-34140 Istanbul, Turkey
[5] Istanbul Univ, Div Gastroenterohepatol, Istanbul Fac Med, TR-34140 Istanbul, Turkey
关键词
Stevens-Johnson syndrome; vanishing bile duct syndrome; ciprofloxacin; tacrolimus;
D O I
10.3748/wjg.14.4697
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Stevens-Johnson syndrome (SIS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient with ciprofloxacin-incluced SIS and acute onset of VBDS, and reviewed the related literature. It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity techniques for diagnosis and methods of management. (c) 2008 The WJG Press. All rights reserved.
引用
收藏
页码:4697 / 4700
页数:4
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