BAM AND BGCN IN DROSOPHILA GERMLINE STEM CELL DIFFERENTIATION

被引：4
作者：
Perinthottathil, Sreejith [1 ]
Kim, Changsoo [1 ]
机构：
[1] Chonnam Natl Univ, Hormone Res Ctr, Sch Biol Sci & Technol, Kwangju, South Korea
来源：
VITAMINS AND HORMONES: STEM CELL REGULATORS | 2011年 / 87卷
关键词：
HUNCHBACK MESSENGER-RNA; CONTROLS SELF-RENEWAL; OF-MARBLES; FEMALE GERMLINE; PUMILIO GENE; BODY PATTERN; BRAIN-TUMOR; OVARY; PROTEIN; NICHE;
D O I：
10.1016/B978-0-12-386015-6.00038-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The female Drosophila reproductive organ, the ovary, has provided researchers with an incisive genetic system with which principle regulation of stern cell maintenance and differentiation has been de. ineated. An environmental niche regulates a stem cell's asymmetric self-renewal division that produces a daughter stem cell and a differentiated daughter cell, which further differentiate into eggs. A number of extrinsic and intrinsic factors have been identified that are required either for stem cell maintenance or differentiation. Bam/Bgcn complex plays a pivotal role in promoting stern cell differentiation. Recent papers suggest that Bam/Bgcn complex regulates translation of important maintenance factors and is also involved in the regulation of microRNA-dependent translational repression. Here, we focus on Barn and Bgcn repression of stem cell maintenance factors in the differentiation of germline stern cells (GSCs). (C) 2011 Elsevier Inc.
引用
收藏
页码：399 / 416
页数：18
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