Mitochondrial calcium handling during ischemia-induced cell death in neurons

被引：67

作者：

Gouriou, Yves ^{[1
]}

Demaurex, Nicolas ^{[1
]}

Bijlenga, Philippe ^{[2
]}

De Marchi, Umberto ^{[1
]}

机构：

[1] Univ Geneva, Dept Cell Physiol & Metab, CH-1211 Geneva, Switzerland

[2] Univ Geneva, Dept Clin Neurosci & Dermatol, CH-1211 Geneva, Switzerland

来源：

BIOCHIMIE | 2011年 / 93卷 / 12期

关键词：

Calcium signaling; Brain diseases; Cerebral ischemia; Apoptosis; Bioenergetics; PERMEABILITY TRANSITION PORE; WOLF-HIRSCHHORN-SYNDROME; GLOBAL BRAIN ISCHEMIA; CYCLOSPORINE-A; CYCLOPHILIN-D; BENZODIAZEPINE-RECEPTOR; REPERFUSION INJURY; POTASSIUM CHANNEL; OXIDATIVE STRESS; POSTISCHEMIC REPERFUSION;

D O I：

10.1016/j.biochi.2011.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria sense and shape cytosolic Ca2+ signals by taking up and subsequently releasing Ca2+ ions during physiological and pathological Ca2+ elevations. Sustained elevations in the mitochondrial matrix Ca2+ concentration are increasingly recognized as a defining feature of the intracellular cascade of lethal events that occur in neurons during cerebral ischemia. Here, we review the recently identified transport proteins that mediate the fluxes of Ca2+ across mitochondria and discuss the implication of the permeability transition pore in decoding the abnormally sustained mitochondrial Ca2+ elevations that occur during cerebral ischemia. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：2060 / 2067

页数：8

共 50 条

[21] Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion
Loor, Gabriel
Kondapalli, Jyothisri
Iwase, Hirotaro
Chandel, Navdeep S.
Waypa, Gregory B.
Guzy, Robert D.
Hoek, Terry L. Vanden
Schumacker, Paul T.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2011, 1813 (07): : 1382 - 1394
[22] PKCε inhibition prevents ischemia-induced dendritic spine impairment in cultured primary neurons
Ge, Chenjie
Wang, Xuefeng
Wang, Yunhong
Lei, Lilei
Song, Guohua
Qian, Mincai
Wang, Shiliang
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023, 25 (04)
[23] The Effects of Atorvastatin on Global Cerebral Ischemia-Induced Neuronal Death
Kho, A. Ra
Hong, Dae Ki
Kang, Beom Seok
Park, Woo-Jung
Choi, Kyung Chan
Park, Kyoung-Ha
Suh, Sang Won
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (09)
[24] ISCHEMIA-INDUCED CHANGE IN CLATHRIN PRECEDING DELAYED NEURONAL DEATH
YOSHIMI, K
IWATA, N
TAKEDA, M
NAKAMURA, Y
NISHIMURA, T
NEUROREPORT, 1995, 6 (03) : 453 - 456
[25] Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains
Rekuviene, Evelina
Ivanoviene, Laima
Borutaite, Vilmante
Morkuniene, Ramune
NEUROSCIENCE LETTERS, 2017, 653 : 45 - 50
[26] Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP
Tajiri, S
Oyadomari, S
Yano, S
Morioka, M
Gotoh, T
Hamada, JI
Ushio, Y
Mori, M
CELL DEATH AND DIFFERENTIATION, 2004, 11 (04) : 403 - 415
[27] Prothymosin α and cell death mode switch, a novel target for the prevention of cerebral ischemia-induced damage
Ueda, Hiroshi
PHARMACOLOGY & THERAPEUTICS, 2009, 123 (03) : 323 - 333
[28] Ischemia-induced neuronal cell death is mediated by the endoplasmic reticulum stress pathway involving CHOP
S Tajiri
S Oyadomari
S Yano
M Morioka
T Gotoh
J-I Hamada
Y Ushio
M Mori
Cell Death & Differentiation, 2004, 11 : 403 - 415
[29] Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death
Marchi, Saverio
Patergnani, Simone
Missiroli, Sonia
Morciano, Giampaolo
Rimessi, Alessandro
Wieckowski, Mariusz R.
Giorgi, Carlotta
Pinton, Paolo
CELL CALCIUM, 2018, 69 : 62 - 72
[30] CaMKII antisense oligodeoxynucleotides protect against ischemia-induced neuronal death in the rat hippocampus
Liu, Zhi'an
Xu, Jing
Shen, Xiaojun
Lv, Chun'e
Xu, Tiejun
Pei, Dongsheng
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2012, 314 (1-2) : 104 - 110

← 1 2 3 4 5 →