Mitochondrial calcium handling during ischemia-induced cell death in neurons

被引：67
|
作者：
Gouriou, Yves [1 ]
Demaurex, Nicolas [1 ]
Bijlenga, Philippe [2 ]
De Marchi, Umberto [1 ]
机构：
[1] Univ Geneva, Dept Cell Physiol & Metab, CH-1211 Geneva, Switzerland
[2] Univ Geneva, Dept Clin Neurosci & Dermatol, CH-1211 Geneva, Switzerland
来源：
BIOCHIMIE | 2011年 / 93卷 / 12期
关键词：
Calcium signaling; Brain diseases; Cerebral ischemia; Apoptosis; Bioenergetics; PERMEABILITY TRANSITION PORE; WOLF-HIRSCHHORN-SYNDROME; GLOBAL BRAIN ISCHEMIA; CYCLOSPORINE-A; CYCLOPHILIN-D; BENZODIAZEPINE-RECEPTOR; REPERFUSION INJURY; POTASSIUM CHANNEL; OXIDATIVE STRESS; POSTISCHEMIC REPERFUSION;
D O I：
10.1016/j.biochi.2011.08.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitochondria sense and shape cytosolic Ca2+ signals by taking up and subsequently releasing Ca2+ ions during physiological and pathological Ca2+ elevations. Sustained elevations in the mitochondrial matrix Ca2+ concentration are increasingly recognized as a defining feature of the intracellular cascade of lethal events that occur in neurons during cerebral ischemia. Here, we review the recently identified transport proteins that mediate the fluxes of Ca2+ across mitochondria and discuss the implication of the permeability transition pore in decoding the abnormally sustained mitochondrial Ca2+ elevations that occur during cerebral ischemia. (C) 2011 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：2060 / 2067
页数：8
相关论文
共 50 条
  • [1] Ischemia-induced programmed cell death in astrocytes
    Giffard, RG
    Swanson, RA
    GLIA, 2005, 50 (04) : 299 - 306
  • [2] Altered mitochondrial calcium handling and cell death by necroptosis: An emerging paradigm
    Faizan, Md Imam
    Ahmad, Tanveer
    MITOCHONDRION, 2021, 57 : 47 - 62
  • [3] Estradiol rescues neurons from global ischemia-induced cell death: Multiple cellular pathways of neuroprotection
    Lebesgue, Diane
    Chevaleyre, Vivien
    Zukin, R. Suzanne
    Etgen, Anne M.
    STEROIDS, 2009, 74 (07) : 555 - 561
  • [4] Late calcium EDTA rescues hippocampal CA1 neurons from global ischemia-induced death
    Calderone, A
    Jover, T
    Mashiko, T
    Noh, K
    Tanaka, H
    Bennett, MVL
    Zukin, RS
    JOURNAL OF NEUROSCIENCE, 2004, 24 (44): : 9903 - 9913
  • [5] Activated Protein C Rescues the Retina from Ischemia-Induced Cell Death
    Du, Zhao-Jiang
    Yamamoto, Takuhiro
    Ueda, Tomoko
    Suzuki, Mihoko
    Tano, Yasuo
    Kamei, Motohiro
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2011, 52 (02) : 987 - 993
  • [6] Molecular participants in mitochondrial cell death channel formation during neuronal ischemia
    Jonas, Elizabeth Ann
    EXPERIMENTAL NEUROLOGY, 2009, 218 (02) : 203 - 212
  • [7] Molecular mechanisms of cerebral ischemia-induced neuronal death
    Hou, ST
    MacManus, JP
    INTERNATIONAL REVIEW OF CYTOLOGY - A SURVEY OF CELL BIOLOGY, VOL 221, 2002, 221 : 93 - 148
  • [8] Neuroprotective effects of silymarin on ischemia-induced delayed neuronal cell death in rat hippocampus
    Hirayama, Koki
    Oshima, Hideki
    Yamashita, Akiko
    Sakatani, Kaoru
    Yoshino, Atsuo
    Katayama, Yoichi
    BRAIN RESEARCH, 2016, 1646 : 297 - 303
  • [9] Neuroprotective effects of nitric oxide donor NOC-18 against brain ischemia-induced mitochondrial damages: role of PKG and PKC
    Arandarcikaite, Odeta
    Jokubka, Ramunas
    Borutaite, Vilmante
    NEUROSCIENCE LETTERS, 2015, 586 : 65 - 70
  • [10] Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide
    Uchida, D
    Arimura, A
    SomogyvariVigh, A
    Shioda, S
    Banks, WA
    BRAIN RESEARCH, 1996, 736 (1-2) : 280 - 286
12345