Regioselective synthesis of multisubstituted pyrazoles via cyclocondensation of β-thioalkyl-α,β-unsaturated ketones with hydrazines

被引：30

作者：

Jin, Weiwei ^{[1
]}

Yu, Haifeng ^{[1
,2
]}

Yu, Zhengkun ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Liaoning, Peoples R China

[2] Anshan Normal Univ, Dept Chem, Anshan 114007, Liaoning, Peoples R China

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 44期

关键词：

COMPLEX CATALYSTS BEARING; OXO KETENE DITHIOACETALS; BESTMANN-OHIRA REAGENT; TRANSFER HYDROGENATION; OXIDATIVE AROMATIZATION; RUTHENIUM(II) COMPLEXES; SUBSTITUTED PYRAZOLES; EFFICIENT SYNTHESIS; IMIDAZOLYL LIGAND; CONSTRUCTION;

D O I：

10.1016/j.tetlet.2011.08.168

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Multisubstituted pyrazoles were efficiently synthesized by cyclocondensation of beta-thioalkyl-alpha,beta-unsaturated ketones with hydrazines under relatively mild conditions. A one-pot synthetic protocol through tandem Liebeskind-Srogl cross-coupling/cyclocondensation using alpha-oxo ketene dithioacetals as the starting materials was also realized for the same purpose. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5884 / 5887

页数：4

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