Iron-Catalyzed Efficient Synthesis of Amides from Aldehydes and Amine Hydrochloride Salts

被引：150

作者：

Ghosh, Subhash Chandra ^{[1
]}

Ngiam, Joyce S. Y. ^{[1
]}

Chai, Christina L. L. ^{[1
,2
]}

Seayad, Abdul M. ^{[1
]}

Tuan Thanh Dang ^{[1
]}

Chen, Anqi ^{[1
]}

机构：

[1] Inst Chem & Engn Sci, Singapore 138665, Singapore

[2] Natl Univ Singapore, Dept Pharm, Singapore 117543, Singapore

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 08期

关键词：

aldehydes; amidation; amides; amine salts; catalysis; iron(II) sulphate; TERT-BUTYL HYDROPEROXIDE; BOND FORMATION; PRIMARY CARBOXAMIDES; OXIDATIVE AMIDATION; STAUDINGER REACTION; COUPLING REAGENTS; SECONDARY AMIDES; ALCOHOLS; TRANSAMIDATION; WATER;

D O I：

10.1002/adsc.201200020

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A practical and efficient method for the synthesis of amides has been developed by iron-catalysed oxidative amidation of aldehydes with amine hydrochloride salts. A wide range of amides have been obtained in good to excellent yields under mild conditions. The application of this novel amide formation reaction to the synthesis of pharmaceutical compounds has been successfully demonstrated.

引用

页码：1407 / 1412

页数：6

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