Imaging in cell-based therapy for neurodegenerative diseases

被引：11

作者：

Kirik, Deniz ^{[1
]}

Breysse, Nathalie ^{[1
]}

Bjoerklund, Tomas ^{[1
]}

Besret, Laurent ^{[2
,3
]}

Hantraye, Philippe ^{[2
,3
]}

机构：

[1] Lund Univ, Sect Neurosci, Dept Expt Med Sci, Wallenberg Neurosci Ctr,Dis Modeling Grp, S-22184 Lund, Sweden

[2] Serv Hosp Frederic Joliot, URA CEA CNRS Isotop Imaging UIIBP Unit 2210, F-91401 Orsay, France

[3] Serv Hosp Frederic Joliot, Program Imagene, F-91401 Orsay, France

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2005年 / 32卷 / Suppl 2期

关键词：

Parkinson's disease; Huntington's disease; cell transplantation; positron emission tomography; magnetic resonance imaging;

D O I：

10.1007/s00259-005-1909-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Fetal cell transplantation for the treatment of Parkinson's and Huntington's diseases has been developed over the past two decades and is now in early clinical testing phase. Direct assessment of the graft's survival, integration into the host brain and impact on neuronal functions requires advanced in vivo neuroimaging techniques. Owing to its high sensitivity, positron emission tomography is today the most widely used tool to evaluate the viability and function of the transplanted tissue in the brain. Nuclear magnetic resonance techniques are opening new possibilities for imaging neurochemical events in the brain. The ultimate goal will be to use the combination of multiple imaging modalities for complete functional monitoring of the repair processes in the central nervous system.

引用

页码：S417 / S434

页数：18

共 152 条

[91] Intracerebral transplantation of fetal ventral mesencephalon for patients with advanced Parkinson's disease - Methodology and 6-month to 1-year follow-up in 3 patients [J].

Levivier, M ;

Dethy, S ;

Rodesch, F ;

Peschanski, M ;

Vandesteene, A ;

David, P ;

Wikler, D ;

Goldman, S ;

Claes, T ;

Biver, F ;

Liesnard, C ;

Goldman, M ;

Hildebrand, J ;

Brotchi, J .

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 1997, 69 (1-4) :99-111

[92]

Lewy F.H., 1912, Handbuch der Neurologie, P920

[93] Economic evidence in parkinson's disease: A review [J].

Lindgren P. .

The European Journal of Health Economics, 2004, 5 (Suppl 1) :S63-S66

[94] GRAFTS OF FETAL DOPAMINE NEURONS SURVIVE AND IMPROVE MOTOR FUNCTION IN PARKINSONS-DISEASE [J].

LINDVALL, O ;

BRUNDIN, P ;

WIDNER, H ;

REHNCRONA, S ;

GUSTAVII, B ;

FRACKOWIAK, R ;

LEENDERS, KL ;

SAWLE, G ;

ROTHWELL, JC ;

MARSDEN, CD ;

BJORKLUND, A .

SCIENCE, 1990, 247 (4942) :574-577

[95]

Lindvall Olle, 2004, NeuroRx, V1, P382

[96] Dyskinesia after fetal cell transplantation for parkinsonism: A PET study [J].

Ma, YL ;

Feigin, A ;

Dhawan, V ;

Fukuda, M ;

Shi, QH ;

Greene, P ;

Breeze, R ;

Fahn, S ;

Freed, C ;

Eidelberg, D .

ANNALS OF NEUROLOGY, 2002, 52 (05) :628-634

[97] A NOVEL GENE CONTAINING A TRINUCLEOTIDE REPEAT THAT IS EXPANDED AND UNSTABLE ON HUNTINGTONS-DISEASE CHROMOSOMES [J].

MACDONALD, ME ;

AMBROSE, CM ;

DUYAO, MP ;

MYERS, RH ;

LIN, C ;

SRINIDHI, L ;

BARNES, G ;

TAYLOR, SA ;

JAMES, M ;

GROOT, N ;

MACFARLANE, H ;

JENKINS, B ;

ANDERSON, MA ;

WEXLER, NS ;

GUSELLA, JF ;

BATES, GP ;

BAXENDALE, S ;

HUMMERICH, H ;

KIRBY, S ;

NORTH, M ;

YOUNGMAN, S ;

MOTT, R ;

ZEHETNER, G ;

SEDLACEK, Z ;

POUSTKA, A ;

FRISCHAUF, AM ;

LEHRACH, H ;

BUCKLER, AJ ;

CHURCH, D ;

DOUCETTESTAMM, L ;

ODONOVAN, MC ;

RIBARAMIREZ, L ;

SHAH, M ;

STANTON, VP ;

STROBEL, SA ;

DRATHS, KM ;

WALES, JL ;

DERVAN, P ;

HOUSMAN, DE ;

ALTHERR, M ;

SHIANG, R ;

THOMPSON, L ;

FIELDER, T ;

WASMUTH, JJ ;

TAGLE, D ;

VALDES, J ;

ELMER, L ;

ALLARD, M ;

CASTILLA, L ;

SWAROOP, M .

CELL, 1993, 72 (06) :971-983

[98] DEFECT IN SUCCINATE OXIDATION BY ISOLATED MUSCLE MITOCHONDRIA IN A PATIENT WITH SYMMETRICAL LESIONS IN THE BASAL GANGLIA [J].

MARTIN, JJ ;

VANDEVYVER, FL ;

SCHOLTE, HR ;

ROODHOOFT, AM ;

CEUTERICK, C ;

MARTIN, L ;

LUYTHOUWEN, IEM .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1988, 84 (2-3) :189-200

[99] Huntington disease: Volumetric, diffusion-weighted, and magnetization transfer MR imaging of brain [J].

Mascalchi, M ;

Lolli, F ;

Della Nave, R ;

Tessa, C ;

Petralli, R ;

Gavazzi, C ;

Politi, LS ;

Macucci, M ;

Filippi, M ;

Piacentini, S .

RADIOLOGY, 2004, 232 (03) :867-873

[100] POSITRON EMISSION TOMOGRAPHY STUDIES OF BRAIN RECEPTORS [J].

MAZIERE, B ;

MAZIERE, M .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1991, 5 (01) :61-91

← 5 6 7 8 9 10 11 12 13 14 →