Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α

被引：20

作者：

Fala, Angela M. ^{[1
]}

Oliveira, Juliana F. ^{[1
]}

Adamoski, Douglas ^{[1
]}

Aricetti, Juliana A. ^{[2
]}

Dias, Marilia M. ^{[1
]}

Dias, Marcio V. B. ^{[1
]}

Sforca, Maurcio L. ^{[1
]}

Lopes-de-Oliveira, Paulo S. ^{[1
]}

Rocco, Silvana A. ^{[1
]}

Caldana, Camila ^{[2
,3
]}

Dias, Sandra M. G. ^{[1
]}

Ambrosio, Andre L. B. ^{[1
]}

机构：

[1] Ctr Nacl Pesquisa Energia & Mat, Lab Nacl Biociencias, BR-13083100 Campinas, SP, Brazil

[2] Ctr Nacl Pesquisa Energia & Mat, Lab Nacl Ciencia & Tecnol Bioetanol, BR-13083100 Campinas, SP, Brazil

[3] Max Plack Partner Grp, Lab Nacl Ciencia & Tecnol Bioetanol, Freiburg, Germany

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

巴西圣保罗研究基金会;

关键词：

PAS-B DOMAIN; DIFFERENTIAL EXPRESSION; SEQUENTIAL ASSIGNMENT; FORCE-FIELD; NMR; PROTEIN; IDENTIFICATION; BINDING; C-13; N-15;

D O I：

10.1038/srep12698

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hypoxia-inducible transcription factors (HIF) form heterodimeric complexes that mediate cell responses to hypoxia. The oxygen-dependent stability and activity of the HIF-alpha subunits is traditionally associated to post-translational modifications such as hydroxylation, acetylation, ubiquitination, and phosphorylation. Here we report novel evidence showing that unsaturated fatty acids are naturally occurring, non-covalent structural ligands of HIF-3 alpha, thus providing the initial framework for exploring its exceptional role as a lipid sensor under hypoxia.

引用

页数：9

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