Decreased recovery of CD4 lymphocytes in older HIV-infected patients beginning highly active antiretroviral therapy

被引：54

作者：

Goetz, MB ^{[1
]}

Boscardin, WJ

Wiley, D

Alkasspooles, S

机构：

[1] VA Greater Los Angeles Healthcare Syst, Dept Med, Los Angeles, CA USA

[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA

[3] Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Sch Nursing, Primary Care Sect, Los Angeles, CA 90024 USA

来源：

AIDS | 2001年 / 15卷 / 12期

关键词：

D O I：

10.1097/00002030-200108170-00017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Among virological responders, the area under the curve of the CD4 count minus baseline (AUCMB) after 3, 9, 15 and 18 months of highly active antiretroviral therapy (HAART) was less in individuals 55 years or older (P < 0.05). Fewer older individuals achieved increases of 50, 100, or over 150 CD4 cells/mul. A random quadratic time course model estimated that the AUCMB decreased 35 cells/year for each 10 years of additional age during the first 12 months after HAART (P < 0.005).

引用

页码：1576 / 1579

页数：4

共 50 条

[21] Autoimmune Diabetes in HIV-Infected Patients on Highly Active Antiretroviral Therapy
Takarabe, Daisuke
Rokukawa, Yuka
Takahashi, Yoshihiko
Goto, Atsushi
Takaichi, Maki
Okamoto, Masahide
Tsujimoto, Tetsuro
Noto, Hiroshi
Kishimoto, Miyako
Kaburagi, Yasushi
Yasuda, Kazuki
Yamamoto-Honda, Ritsuko
Tsukada, Kunihisa
Honda, Miwako
Teruya, Katsuji
Kajio, Hiroshi
Kikuchi, Yoshimi
Oka, Shinichi
Noda, Mitsuhiko
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2010, 95 (08): : 4056 - 4060
[22] Dyspepsia in HIV-infected patients under highly active antiretroviral therapy
Werneck-Silva, Ana Luiza
Prado, Ivete Bedin
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2007, 22 (11) : 1712 - 1716
[23] Anemia in HIV-infected patients receiving highly active antiretroviral therapy
Moore, RD
Forney, D
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2002, 29 (01) : 54 - 57
[24] Factors associated with long-term CD4 cell recovery in HIV-infected patients on successful antiretroviral therapy
Collazos, J.
Valle-Garay, E.
Carton, J. A.
Montes, A. H.
Suarez-Zarracina, T.
De la Fuente, B.
Asensi, V.
HIV MEDICINE, 2016, 17 (07) : 532 - 541
[25] Establishing CD4 thresholds for highly active antiretroviral therapy initiation in a cohort of HIV-infected adult Chinese in Hong Kong
Wong, K. A. Hing
Chan, Kenny Chi Wai
Cheng, Kathy Lai Sim
Chan, Wai Kit
Kam, Kai Man
Lee, Shui Shan
AIDS PATIENT CARE AND STDS, 2007, 21 (02) : 106 - 115
[26] Baseline thymic volume is a predictor for CD4 T cell repopulation in adult HIV-infected patients under highly active antiretroviral therapy
de la Rosa, R
Leal, M
Rubio, A
Martinez-Moya, M
Delgado, J
Ruíz-Mateos, E
Merchante, E
Sánchez-Quijano, A
Lissen, E
ANTIVIRAL THERAPY, 2002, 7 (03) : 159 - 163
[27] Immunological nonresponse to highly active antiretroviral therapy in HIV-infected subjects: Is the bone marrow impairment causing CD4 lymphopenia?
Badolato, Raffaele
CLINICAL INFECTIOUS DISEASES, 2008, 46 (12) : 1911 - 1912
[28] CD4+CD7- lymphocyte subset is expanded in HIV-infected patients with low CD4 cell count rescue during highly active antiretroviral therapy
Meroni, L
Varchetta, S
Manganaro, D
Moscatelli, G
Moroni, M
Galli, M
AIDS, 1999, 13 (05) : 621 - 622
[29] The impact of prescribed opioids on CD4 cell count recovery among HIV-infected patients newly initiating antiretroviral therapy
Edelman, E. J.
Gordon, K. S.
Tate, J. P.
Becker, W. C.
Bryant, K.
Crothers, K.
Gaither, J. R.
Gibert, C. L.
Gordon, A. J.
Marshall, B. D. L.
Rodriguez-Barradas, M. C.
Samet, J. H.
Skanderson, M.
Justice, A. C.
Fiellin, D. A.
HIV MEDICINE, 2016, 17 (10) : 728 - 739
[30] CD4 cell recovery during successful antiretroviral therapy in naive HIV-infected patients:: the role of intravenous drug use
Dronda, F
Zamora, J
Moreno, S
Moreno, A
Casado, JL
Muriel, A
Pérez-Elías, MJ
Antela, A
Moreno, L
Quereda, C
AIDS, 2004, 18 (16) : 2210 - 2212

← 1 2 3 4 5 →