Decreased recovery of CD4 lymphocytes in older HIV-infected patients beginning highly active antiretroviral therapy

被引：54

作者：

Goetz, MB ^{[1
]}

Boscardin, WJ

Wiley, D

Alkasspooles, S

机构：

[1] VA Greater Los Angeles Healthcare Syst, Dept Med, Los Angeles, CA USA

[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA

[3] Univ Calif Los Angeles, Dept Biostat, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Sch Nursing, Primary Care Sect, Los Angeles, CA 90024 USA

来源：

AIDS | 2001年 / 15卷 / 12期

关键词：

D O I：

10.1097/00002030-200108170-00017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Among virological responders, the area under the curve of the CD4 count minus baseline (AUCMB) after 3, 9, 15 and 18 months of highly active antiretroviral therapy (HAART) was less in individuals 55 years or older (P < 0.05). Fewer older individuals achieved increases of 50, 100, or over 150 CD4 cells/mul. A random quadratic time course model estimated that the AUCMB decreased 35 cells/year for each 10 years of additional age during the first 12 months after HAART (P < 0.005).

引用

页码：1576 / 1579

页数：4

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