Role of Oxidative RNA Damage in Chronic-Degenerative Diseases

被引:49
作者
Fimognari, Carmela [1 ]
机构
[1] Alma Mater Studiorum Univ Bologna, Dept Life Qual Studies, I-47921 Rimini, Italy
关键词
SPRAGUE-DAWLEY RATS; MESSENGER-RNA; NITRIC-OXIDE; DNA-DAMAGE; PARKINSONS-DISEASE; ALZHEIMER-DISEASE; RIBOSOMAL-RNA; OXIDIZED RNAS; EARLY EVENT; LIVER DNA;
D O I
10.1155/2015/358713
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Normal cellular metabolism and exposure to ionizing and ultraviolet radiations and exogenous agents produce reactive oxygen species (ROS). Due to their reactivity, they can interact with many critical biomolecules and induce cell damage. The reaction of ROS with free nucleobases, nucleosides, nucleotides, or oligonucleotides can generate numerous distinct modifications in nucleic acids. Oxidative damage to DNA has been widely investigated and is strongly implicated in the development of many chronic-degenerative diseases. In contrast, RNA damage is a poorly examined field in biomedical research. In this review, I discuss the importance of RNA as a target of oxidative damage and the role of oxidative damage to RNA in the pathogenesis of some chronic-degenerative diseases, such as neurological disorders, atherosclerosis, and cancer. Furthermore, I review recent evidence suggesting that RNA may be the target for toxic agents and indicating RNA degradation as a powerful tool to treat any pathology in which there is an aberrant expression of mRNA and/or its gene products.
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页数:8
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