Evaluation of antimalarial, free-radical-scavenging and insecticidal activities of Artemisia scoparia and A. spicigera, Asteraceae

被引：29

作者：

Afshar, Fariba H. ^{[2
,3
]}

Delazar, Abbas ^{[2
,3
]}

Janneh, Omar ^{[4
]}

Nazemiyeh, Hossein ^{[5
]}

Pasdaran, Ardalan ^{[5
]}

Nahar, Lutfun ^{[1
]}

Sarker, Satyajit D. ^{[1
]}

机构：

[1] Wolverhampton Univ, Dept Pharm, Sch Appl Sci, Drug Discovery & Design Res Div, Wolverhampton WV1 1SB, W Midlands, England

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz, Iran

[4] Coventry Univ, Dept Biomol & Sport Sci, Coventry, W Midlands, England

[5] Tabriz Univ Med Sci, Sch Pharm, Tabriz, Iran

来源：

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY | 2011年 / 21卷 / 06期

关键词：

Artemisia scoparia; Artemisia spicigera; Asteraceae; DPPH; antimalaria; insecticide; FARNESYL-PROTEIN TRANSFERASE; RIBES-BIEBERSTEINII BERL; BETA-HEMATIN FORMATION; GC-MS ANALYSIS; CHEMICAL-COMPOSITION; ESSENTIAL OILS; AERIAL PARTS; FERRIPROTOPORPHYRIN IX; INHIBITION; 3-O-GLYCOSIDES;

D O I：

10.1590/S0102-695X2011005000144

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Artemisia species (Asteraceae), widespread throughout the world, are a group of important medicinal plants. The extracts of two medicinal plants of this genus, Artemisia scoparia Waldst. & Kit. and A. spicigera C. Koch, were evaluated for potential antimalarial, free-radical-scavenging and insecticidal properties, using the heme biocrystallisation and inhibition assay, the DPPH assay and the contact toxicity bioassay using the pest Tribolium castaneum, respectively. The methanol extracts of both species showed strong free-radical-scavenging activity and the RC50 values were 0.0317 and 0.0458 mg/mL, respectively, for A. scoparia and A. spicigera. The dichloromethane extracts of both species displayed a moderate level of potential antimalarial activity providing IC50 at 0.778 and 0.999 mg/mL for A. scoparia and A. spicigera, respectively. Both species of Artemisia showed insecticidal properties. However, A. spicigera was more effective than A. scoparia.

引用

页码：986 / 990

页数：5

共 39 条

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