Baicalin suppresses the migration and invasion of breast cancer cells via the TGF-β/lncRNA-MALAT1/miR-200c signaling pathway

被引：19

作者：

Li, Jiafeng ^{[1
]}

Liu, Huixin ^{[2
,3
]}

Lin, Qiwang ^{[1
]}

Chen, Huajiao ^{[1
]}

Liu, Liya ^{[2
,3
]}

Liao, Hongjuan ^{[1
]}

Cheng, Ying ^{[2
,3
]}

Zhang, Xiuli ^{[2
,3
]}

Wang, Zhenlong ^{[2
,3
]}

Shen, Aling ^{[2
,3
]}

Chen, Guolong ^{[1
]}

机构：

[1] Fujian Matern & Child Hlth Hosp, Dept Pharm Dept, Fuzhou, Fujian, Peoples R China

[2] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou, Fujian, Peoples R China

[3] Fujian Univ Tradit Chinese Med, Fujian Key Lab Integrat Med Geriatr, Fuzhou, Fujian, Peoples R China

来源：

MEDICINE | 2022年 / 101卷 / 46期

基金：

中国国家自然科学基金;

关键词：

baicalin; breast cancer; invasion; migration; TGF-beta; lncRNA-MALAT1; miR-200c; EPITHELIAL-MESENCHYMAL TRANSITION; LONG NONCODING RNAS; MIR-200; FAMILY; E-CADHERIN; TGF-BETA; METASTASIS; EXPRESSION; ZEB1; EMT; APOPTOSIS;

D O I：

10.1097/MD.0000000000029328

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Metastasis is the major cause of death and failure of cancer chemotherapy in patients with breast cancer (BC). Activation of TGF-beta/lncRNA-MALAT1/miR-200c has been reported to play an essential role during the metastasis of BC cells. The present study aimed to validate the suppression of BC-cell migration and invasion by baicalin and explore its regulatory effects on the TGF-beta/lncRNA-MALAT1/miR-200c signaling pathway. We found that baicalin treatment inhibited cell viability and migration and invasion. Mechanistically, baicalin treatment significantly downregulated the expression of TGF-beta, ZEB1, and N-cadherin and upregulated E-cadherin on both mRNA and protein levels. Additionally, baicalin treatment significantly downregulated the expression of lncRNA-MALAT1 and upregulated that of miR-200c. Collectively, baicalin significantly suppresses cell viability, migration, and invasion of BC cells possibly by regulating the TGF-beta/lncRNA-MALAT1/miR-200c pathway.

引用

页数：7

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