Expression of c-fos in the rat brainstem after chronic intermittent hypoxia

被引：87

作者：

Greenberg, HE ^{[1
]}

Sica, AL

Scharf, SM

Ruggiero, DA

机构：

[1] Long Isl Jewish Med Ctr, Div Pulm & Crit Care Med, New Hyde Park, NY 11040 USA

[2] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA

[3] Columbia Univ Coll Phys & Surg, Dept Anat & Cell Biol, New York, NY 10032 USA

[4] Neurol Res Inst Lubec, Lubec, ME 04652 USA

来源：

BRAIN RESEARCH | 1999年 / 816卷 / 02期

基金：

美国国家卫生研究院;

关键词：

intermittent hypoxia c-fos; sympathetic nervous system; obstructive sleep apnea;

D O I：

10.1016/S0006-8993(98)01222-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic intermittent hypoxia(CIH) may cause sustained systemic hypertension by increasing sympathetic neural discharge (SND). We hypothesized that CM alters brainstem circuits modulating SND. After 30 days of CIH exposure in rats, increased c-fas labeling was seen in the nucleus of the solitary tract and ventrolateral medulla as well as other brainstem regions involved in regulation of SND. Increased expression of c-fas after CIH may indicate changes in neuronal genetic transcription which ultimately modulate SND. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：638 / 645

页数：8

共 50 条

[21] Chronic Intermittent Hypoxia Alters Genioglossus Motor Unit Discharge Patterns in the Anaesthetized Rat [J].

Edge, Deirdre ;

Bradford, Aidan ;

Jones, James F. X. ;

O'Halloran, Ken D. .

ARTERIAL CHEMORECEPTION: FROM MOLECULES TO SYSTEMS, 2012, 758 :295-300

[22] Effect of chronic intermittent hypoxia on leptin and leptin receptor protein expression in the carotid body [J].

Messenger, Scott A. ;

Moreau, Jason M. ;

Ciriello, John .

BRAIN RESEARCH, 2013, 1513 :51-60

[23] Chronic Intermittent Hypoxia Exerts CNS Region-Specific Effects on Rat Microglial Inflammatory and TLR4 Gene Expression [J].

Smith, Stephanie M. C. ;

Friedle, Scott A. ;

Watters, Jyoti J. .

PLOS ONE, 2013, 8 (12)

[24] Altered sympathetic reflexes and vascular reactivity in rats after exposure to chronic intermittent hypoxia [J].

Silva, Ana Q. ;

Schreihofer, Ann M. .

JOURNAL OF PHYSIOLOGY-LONDON, 2011, 589 (06) :1463-1476

[25] The neuroprotective effects of grape seed proanthocyanidin on rat brain injury caused by chronic intermittent hypoxia [J].

Zhao, Ya-Ning ;

Guo, Xia ;

Wang, Hong-Yang ;

Li, Lin ;

Zhang, Pan-Pan ;

Han, Xiao-Qing ;

Liu, Wen-Qian .

NEUROLOGY ASIA, 2014, 19 (04) :399-403

[26] Effect of Chronic Intermittent Hypoxia on the Reflex Recruitment of the Genioglossus During Airway Obstruction in the Anesthetized Rat [J].

Edge, Deirdre ;

McDonald, Fiona B. ;

Jones, James F. X. ;

Bradford, Aidan ;

O'Halloran, Ken D. .

CENTRAL NERVOUS SYSTEM CONTROL OF RESPIRATION, 2014, 209 :147-168

[27] Chronic intermittent hypoxia induces cardiac inflammation and dysfunction in a rat obstructive sleep apnea model [J].

Wei, Qin ;

Bian, Yeping ;

Yu, Fuchao ;

Zhang, Qiang ;

Zhang, Guanghao ;

Li, Yang ;

Song, Songsong ;

Ren, Xiaomei ;

Tong, Jiayi .

JOURNAL OF BIOMEDICAL RESEARCH, 2016, 30 (06) :490-495

[28] Effects of Gestational and Postnatal Exposure to Chronic Intermittent Hypoxia on Diaphragm Muscle Contractile Function in the Rat [J].

McDonald, Fiona B. ;

Dempsey, Eugene M. ;

O'Halloran, Ken D. .

FRONTIERS IN PHYSIOLOGY, 2016, 7

[29] Chronic intermittent asphyxia impairs rat upper airway muscle responses to acute hypoxia and asphyxia [J].

O'Halloran, KD ;

McGuire, M ;

O'Hare, T ;

Bradford, A .

CHEST, 2002, 122 (01) :269-275

[30] Ocular Inflammation and Oxidative Stress as a Result of Chronic Intermittent Hypoxia: A Rat Model of Sleep Apnea [J].

Donkor, Nina ;

Gardner, Jennifer J. ;

Bradshaw, Jessica L. ;

Cunningham, Rebecca L. ;

Inman, Denise M. .

ANTIOXIDANTS, 2024, 13 (07)

← 1 2 3 4 5 →