Expression of c-fos in the rat brainstem after chronic intermittent hypoxia

被引：86

作者：

Greenberg, HE ^{[1
]}

Sica, AL

Scharf, SM

Ruggiero, DA

机构：

[1] Long Isl Jewish Med Ctr, Div Pulm & Crit Care Med, New Hyde Park, NY 11040 USA

[2] Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA

[3] Columbia Univ Coll Phys & Surg, Dept Anat & Cell Biol, New York, NY 10032 USA

[4] Neurol Res Inst Lubec, Lubec, ME 04652 USA

来源：

BRAIN RESEARCH | 1999年 / 816卷 / 02期

基金：

美国国家卫生研究院;

关键词：

intermittent hypoxia c-fos; sympathetic nervous system; obstructive sleep apnea;

D O I：

10.1016/S0006-8993(98)01222-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic intermittent hypoxia(CIH) may cause sustained systemic hypertension by increasing sympathetic neural discharge (SND). We hypothesized that CM alters brainstem circuits modulating SND. After 30 days of CIH exposure in rats, increased c-fas labeling was seen in the nucleus of the solitary tract and ventrolateral medulla as well as other brainstem regions involved in regulation of SND. Increased expression of c-fas after CIH may indicate changes in neuronal genetic transcription which ultimately modulate SND. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：638 / 645

页数：8

共 26 条

[1] Regulation of vasopressin synthesis and release by area postrema in rats [J].

Arima, H ;

Kondo, K ;

Murase, T ;

Yokoi, H ;

Iwasaki, Y ;

Saito, H ;

Oiso, Y .

ENDOCRINOLOGY, 1998, 139 (04) :1481-1486

[2] Central pathways subserving the baroreceptor reflex in conscious animals: Studies using c-fos gene expression [J].

Dampney, RAL ;

Polson, JW ;

Potts, PD ;

Li, YW ;

Hirooka, Y .

FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1997, 11 :S11-S15

[3] THE USE OF C-FOS AS A METABOLIC MARKER IN NEURONAL PATHWAY TRACING [J].

DRAGUNOW, M ;

FAULL, R .

JOURNAL OF NEUROSCIENCE METHODS, 1989, 29 (03) :261-265

[4] HYPOXIA AND ELECTRICAL-STIMULATION OF THE CAROTID-SINUS NERVE INDUCE FOS-LIKE IMMUNOREACTIVITY WITHIN CATECHOLAMINERGIC AND SEROTONINERGIC NEURONS OF THE RAT BRAIN-STEM [J].

ERICKSON, JT ;

MILLHORN, DE .

JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 348 (02) :161-182

[5] THE CENTRAL ORGANIZATION OF CAROTID-BODY AFFERENT-PROJECTIONS TO THE BRAIN-STEM OF THE RAT [J].

FINLEY, JCW ;

KATZ, DM .

BRAIN RESEARCH, 1992, 572 (1-2) :108-116

[6] REPETITIVE, EPISODIC HYPOXIA CAUSES DIURNAL ELEVATION OF BLOOD-PRESSURE IN RATS [J].

FLETCHER, EC ;

LESSKE, J ;

WEI, Q ;

MILLER, CC ;

UNGER, T .

HYPERTENSION, 1992, 19 (06) :555-561

[7] CAROTID CHEMORECEPTORS, SYSTEMIC BLOOD-PRESSURE, AND CHRONIC EPISODIC HYPOXIA MIMICKING SLEEP-APNEA [J].

FLETCHER, EC ;

LESSKE, J ;

BEHM, R ;

MILLER, CC ;

STAUSS, H ;

UNGER, T .

JOURNAL OF APPLIED PHYSIOLOGY, 1992, 72 (05) :1978-1984

[8] URINARY CATECHOLAMINES BEFORE AND AFTER TRACHEOSTOMY IN PATIENTS WITH OBSTRUCTIVE SLEEP-APNEA AND HYPERTENSION [J].

FLETCHER, EC ;

MILLER, J ;

SCHAAF, JW ;

FLETCHER, JG .

SLEEP, 1987, 10 (01) :35-44

[9] SYMPATHETIC DENERVATION BLOCKS BLOOD-PRESSURE ELEVATION IN EPISODIC HYPOXIA [J].

FLETCHER, EC ;

LESSKE, J ;

CULMAN, J ;

MILLER, CC ;

UNGER, T .

HYPERTENSION, 1992, 20 (05) :612-619

[10]

GREENBERG HE, IN PRESS J APPL PHYS

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