Epigenetic Regulation of Hepatic Lipogenesis: Role in Hepatosteatosis and Diabetes

被引:28
|
作者
Viscarra, Jose [1 ]
Sul, Hei Sook [1 ]
机构
[1] Univ Calif Berkeley, Nutr Sci & Toxicol, Berkeley, CA 94720 USA
关键词
FATTY-ACID; GENE-EXPRESSION; LXR-ALPHA; LIVER; BINDING; ACTIVATION; RECEPTORS; CHROMATIN; GLUCOSE; OBESITY;
D O I
10.2337/dbi18-0032
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hepatosteatosis, which is frequently associated with development of metabolic syndrome and insulin resistance, manifests when triglyceride (TG) input in the liver is greater than TG output, resulting in the excess accumulation of TG. Dysregulation of lipogenesis therefore has the potential to increase lipid accumulation in the liver, leading to insulin resistance and type 2 diabetes. Recently, efforts have been made to examine the epigenetic regulation of metabolism by histone-modifying enzymes that alter chromatin accessibility for activation or repression of transcription. For regulation of lipogenic gene transcription, various known lipogenic transcription factors, such as USF1, ChREBP, and LXR, interact with and recruit specific histone modifiers, directing specificity toward lipogenesis. Alteration or impairment of the functions of these histone modifiers can lead to dysregulation of lipogenesis and thus hepatosteatosis leading to insulin resistance and type 2 diabetes.
引用
收藏
页码:525 / 531
页数:7
相关论文
共 50 条
  • [1] Transcriptional regulation of lipogenesis and its contribution to hepatosteatosis
    Wang, Yuhui
    Sul, Hei Sook
    CLINICAL LIPIDOLOGY, 2013, 8 (02) : 165 - 168
  • [2] Transcriptional regulation of hepatic lipogenesis
    Wang, Yuhui
    Viscarra, Jose
    Kim, Sun-Joong
    Sul, Hei Sook
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2015, 16 (11) : 678 - 689
  • [3] Transcriptional regulation of hepatic lipogenesis
    Yuhui Wang
    Jose Viscarra
    Sun-Joong Kim
    Hei Sook Sul
    Nature Reviews Molecular Cell Biology, 2015, 16 : 678 - 689
  • [4] The Role of Epigenetic Regulation in Diabetes and Its Complications
    Ling Hong-Yan
    Hu Bi
    Feng Shui-Dong
    Liao Duan-Fang
    Wen Ge-Bo
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2012, 39 (01) : 14 - 21
  • [5] THE ROLE OF INSULIN MEDIATORS IN REGULATION OF cAMP AND LIPOGENESIS AS WELL AS IN DIABETES
    张世荣
    魏铁拳
    姚文贞
    韩锦华
    幸兴球
    王越
    王敬泽
    乐云
    Science in China,SerB, 1987, Ser.B1987 (08) : 832 - 841
  • [6] THE ROLE OF INSULIN MEDIATORS IN REGULATION OF CAMP AND LIPOGENESIS AS WELL AS IN DIABETES
    ZHANG, SR
    WEI, TQ
    YAO, WZ
    HAN, JH
    XING, XQ
    WANG, Y
    WANG, JZ
    YUE, Y
    SCIENTIA SINICA SERIES B-CHEMICAL BIOLOGICAL AGRICULTURAL MEDICAL & EARTH SCIENCES, 1987, 30 (08) : 832 - 841
  • [7] Erratum: Transcriptional regulation of hepatic lipogenesis
    Yuhui Wang
    Jose Viscarra
    Sun-Joong Kim
    Hei Sook Sul
    Nature Reviews Molecular Cell Biology, 2016, 17 : 64 - 64
  • [8] NUTRITIONAL REGULATION OF HEPATIC LIPOGENESIS IN THE RAT
    KELLEY, DS
    NELSON, GJ
    SERRATO, CM
    SCHMIDT, PC
    NUTRITION RESEARCH, 1987, 7 (05) : 509 - 517
  • [9] Regulation of Hepatic de novo Lipogenesis
    Chen, Qing
    Rabinowitz, Joshua D.
    Birnbaum, Morris J.
    DIABETES, 2012, 61 : A465 - A465
  • [10] ROLE OF PROLACTIN ON THE REGULATION OF HEPATIC LIPOGENESIS INVIVO DURING LATE GESTATION IN THE RAT
    BENITO, M
    LORENZO, M
    MEDINA, JM
    HORMONE AND METABOLIC RESEARCH, 1982, 14 (11) : 614 - 615