Osteosarcopenia: where osteoporosis and sarcopenia collide

被引:146
作者
Clynes, Michael A. [1 ]
Gregson, Celia L. [2 ]
Bruyere, Olivier [3 ]
Cooper, Cyrus [1 ,4 ,5 ,6 ]
Dennison, Elaine M. [1 ]
机构
[1] Univ Southampton, Southampton Gen Hosp, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England
[2] Univ Bristol, Bristol Med Sch, Musculoskeletal Res Unit, Bristol, Avon, England
[3] Univ Liege, WHO Collaborating Ctr Publ Hlth Aspects Musculosk, Div Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium
[4] Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England
[5] Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England
[6] Univ Oxford, NIHR Oxford Biomed Res Unit, Oxford, England
关键词
bone; muscle; osteoporosis; sarcopenia; osteosarcopenia; falls; fracture; strength; BONE-MINERAL DENSITY; C-REACTIVE PROTEIN; SKELETAL-MUSCLE MASS; VITAMIN-D; FRACTURE RISK; DIETARY-PROTEIN; OLDER-ADULTS; INFLAMMATORY MARKERS; POSTMENOPAUSAL WOMEN; VERTEBRAL FRACTURES;
D O I
10.1093/rheumatology/keaa755
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The coexistence of osteoporosis and sarcopenia has been recently considered in some groups as a syndrome termed 'osteosarcopenia'. Osteoporosis describes low bone mass and deterioration of the micro-architecture of the bone, whereas sarcopenia is the loss of muscle mass, strength and function. With an ageing population the prevalence of both conditions is likely to increase substantially over the coming decades and is associated with significant personal and societal burden. The sequelae for an individual suffering from both conditions together include a greater risk of falls, fractures, institutionalization and mortality. The aetiology of 'osteosarcopenia' is multifactorial with several factors linking muscle and bone function, including genetics, age, inflammation and obesity. Several biochemical pathways have been identified that are facilitating the development of several promising therapeutic agents, which target both muscle and bone. In the current review we outline the epidemiology, pathogenesis and clinical consequences of 'osteosarcopenia' and explore current and potential future management strategies.
引用
收藏
页码:529 / 537
页数:9
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