Astrocyte elevated gene-1 promotes tumour growth and invasion by inducing EMT in oral squamous cell carcinoma

被引：10

作者：

Wang, Yan ^{[1
]}

Wang, Ting ^{[1
]}

Sun, Yunduan ^{[2
]}

Sun, Wenjing ^{[3
]}

Wang, Xiumei ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 2, Dept Dent, Harbin 150086, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 1, Dept Ophthalmol, Harbin 150001, Heilongjiang, Peoples R China

[3] Harbin Med Univ, Lab Med Genet, Harbin 150001, Heilongjiang, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; CANCER PROGRESSION; BREAST-CANCER; METASTASIS; AEG-1; PROLIFERATION; METADHERIN; ACTIVATION; EXPRESSION;

D O I：

10.1038/s41598-017-15805-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oral squamous cell carcinoma (OSCC) is a common human malignancy with a high incidence rate and poor prognosis. Although astrocyte elevated gene 1 (AEG-1) expression is up-regulated in various human cancers and plays an important role in carcinogenesis and tumour progression, the impact of AEG-1 on the development and progression of OSCC remains unclear. Accordingly, this study aims to clarify the biological significance of AEG-1 in OSCC. We found AEG-1 to be overexpressed in OSCC tissues compared to normal oral mucosa. Knockdown or overexpression of AEG-1 in OSCC cell lines showed that AEG-1 is important for tumour growth, apoptosis, drug tolerance, and maintaining epithelial-mesenchymal transition (EMT)-mediated cell migration and invasion in vitro. Moreover, in a xenograft-mouse model generated by AEG-1-overexpressing SCC15 cells, we found that higher expression of AEG-1 promoted tumour growth, angiogenesis, and EMT in vivo. These findings provide mechanistic insight into the role of AEG-1 in regulating OSCC tumour growth, apoptosis, drug tolerance, and invasion, as well as AEG-1-induced activation of p38 and NF-kappa B signalling, suggesting that AEG-1 is an important prognostic factor and therapeutic target for OSCC.

引用

页数：12

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