Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice

被引:13
作者
Liu, Hao [1 ]
Ou, Mei-Xian [2 ,3 ]
Han, Qiao-Qiao [4 ]
机构
[1] Ningbo Univ, Zhejiang Prov Key Lab Pathophysiol, Translat Med Ctr Pain Emot & Cognit, Ningbo Key Lab Behav Neurosci,Sch Med, Ningbo, Peoples R China
[2] Shanghai Xuhui Cent Hosp, Shanghai Engn Res Ctr Phase 1, Shanghai, Peoples R China
[3] Shanghai Xuhui Cent Hosp, Qual Consistency Evaluat Drugs & Cent Lab, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, State Key Lab Oncogenes & Related Genes, Shanghai Inst Immunol,Dept Immunol & Microbiol, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
morroniside; interleukin-10; M2; polarization; middle cerebral artery occlusion; ischemic stroke; ATTENUATES NEUROPATHIC PAIN; GLP-1; RECEPTOR; ACTIVATION; EXPRESSION; IL-10;
D O I
10.3389/fphar.2021.784329
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Morroniside, a secoiridoid glycoside from Cornus officinalis, is a class of small molecule non-peptide glucagon-like peptide-1 receptor (GLP-1R) agonists and possess many important biomedical functions. Our previous studies reported that GLP-1R agonist exenatide promoted M2 polarization and the expression of cell-specific anti-inflammatory factor interleukin-10 in neuropathological pain model. In this study, we proved that morroniside not only induced M2 polarization and stimulated interleukin-10 expression specifically in cortical primary microglia by p38 beta mitogen-activated protein kinases pathway but also protected nerve cells against H2O2-induced cell oxidative damage and prohibited ischemic injury by reducing infarct size, which is at least in part mediated by enhanced expression of microglial interleukin-10. In the cortical penumbra area in middle cerebral artery occlusion (MCAO) mice. In general, our results indicated that GLP-1R agonist morroniside might play a neuroprotective effect by inducing M2 polarization, and cyclic-AMP/protein kinase A/p38 beta pathway might mediate morroniside-induced expression of interleukin-10 protein in M2 microglia.
引用
收藏
页数:9
相关论文
共 30 条
  • [1] Protective effects of the GLP-1 mimetic exendin-4 in Parkinson's disease
    Athauda, Dilan
    Foltynie, Thomas
    [J]. NEUROPHARMACOLOGY, 2018, 136 : 260 - 270
  • [2] Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases
    Batista, Andre F.
    Bodart-Santos, Victor
    De Felice, Fernanda G.
    Ferreira, Sergio T.
    [J]. CNS DRUGS, 2019, 33 (03) : 209 - 223
  • [3] Morroniside prevents H2O2 or Aβ1-42-induced apoptosis via attenuating JNK and p38 MAPK phosphorylation
    Chen, Kang
    Lu, Yunwei
    Liu, Chenyang
    Zhang, Limi
    Fang, Zhuyuan
    Yu, Guran
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2018, 834 : 295 - 304
  • [4] Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors
    Gong, Nian
    Fan, Hui
    Ma, Ai-Niu
    Xiao, Qi
    Wang, Yong-Xiang
    [J]. NEUROPHARMACOLOGY, 2014, 84 : 31 - 45
  • [5] Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity
    Gong, Nian
    Xiao, Qi
    Zhu, Bin
    Zhang, Chang-Yue
    Wang, Yan-Chao
    Fan, Hui
    Ma, Ai-Niu
    Wang, Yong-Xiang
    [J]. JOURNAL OF NEUROSCIENCE, 2014, 34 (15) : 5322 - 5334
  • [6] The role of peripheral monocytes and macrophages in ischemic stroke
    Han, Dong
    Liu, Hang
    Gao, Yan
    [J]. NEUROLOGICAL SCIENCES, 2020, 41 (12) : 3589 - 3607
  • [7] p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ji, RR
    Samad, TA
    Jin, SX
    Schmoll, R
    Woolf, CJ
    [J]. NEURON, 2002, 36 (01) : 57 - 68
  • [8] Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    Johnson, GL
    Lapadat, R
    [J]. SCIENCE, 2002, 298 (5600) : 1911 - 1912
  • [9] TRANSCRIPTOMIC ANALYSIS REVEALS DIFFERENTIAL ACTIVATION OF MICROGLIAL GENES AFTER ISCHEMIC STROKE IN MICE
    Khan, Akbar
    Ju, Furong
    Xie, Wenguang
    Hafeez, Muhammad Tariq
    Cheng, Xiaofeng
    Yang, Zhijie
    Zhu, Lirui
    Li, Ting
    Zhang, Shengxiang
    [J]. NEUROSCIENCE, 2017, 348 : 212 - 227
  • [10] Kilkenny C, 2010, BRIT J PHARMACOL, V160, P1577, DOI [10.1038/jcbfm.2010.220, 10.1111/j.1476-5381.2010.00872.x]