Epigenetic protein complexes: the adequate candidates for the use of a new generation of epidrugs in personalized and precision medicine in cancer

被引：9
|
作者：
Cartron, Pierre-Francois [1 ,2 ,3 ,4 ,5 ]
Cheray, Mathilde [6 ]
Bretaudeau, Laurent [7 ]
机构：
[1] Univ Nantes, INSERM, CRCINA, Nantes, France
[2] Inst Cancerol Ouest, LaBCT, Equipe Apoptose & Progress Tumorale, St Herblain, France
[3] Niches & Epigenet Tumors Network, Canceropole Grand Ouest, Nantes, France
[4] EpiSAVMEN Consortium, Nantes, Region De La Pa, France
[5] Univ Nantes, LabEX IGO, Nantes, France
[6] Karolinska Inst, Toxicol Unit, Inst Environm Med, Stockholm 17177, Sweden
[7] LB4Biotech, Nantes, France
来源：
EPIGENOMICS | 2020年 / 12卷 / 02期
关键词：
(epigenetic player/protein-X disruptor); DNMT inhibitors; epidrugs; epigenetics; high resolution DNA methylation; high selective drug; personalized medicine; protein-protein interactions; INHIBITOR; DNMT1; TRANSCRIPTION; EPIGENOMICS; DYNAMICS;
D O I：
10.2217/epi-2019-0169
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Until recently, drug development in oncology was focused on treating most patients for a specific cancer type without taking in account the heterogeneity between these patients in term of response to treatment. Therefore, this type of broad treatment approach excludes the treatment of patient not responding to disease-specific common drugs. In this review, we focus on the different types of epigenetic drugs currently used as DNA methylation inhibitor agents and their limits in patient care due to their lack of specificity. We also highlight the emergence of a new type of epidrug with higher target specificity due to their original mechanism of action: the disruption of protein complexes involved in the epigenetic modifications.
引用
收藏
页码：171 / 177
页数：7
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