Confinement of a tris-aqua Gd(III) complex in silica nanoparticles leads to high stability and high relaxivity and supresses anion binding

被引：13

作者：

Karimdjy, Maria Moula ^{[1
,2
]}

Tallec, Gaylord ^{[1
,2
]}

Fries, Pascal H. ^{[1
,2
]}

Imbert, Daniel ^{[1
,2
]}

Mazzanti, Marinella ^{[3
]}

机构：

[1] Univ Grenoble Alpes, INAC LCIB, RICC, F-38000 Grenoble, France

[2] CEA Grenoble, INAC LCIB, F-38000 Grenoble, France

[3] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 31期

关键词：

MRI CONTRAST AGENTS; GADOLINIUM COMPLEX; SENSITIVITY; RELAXATION; DYNAMICS;

D O I：

10.1039/c5cc01352f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The water soluble tris-aqua complex [Gd(dhqN-SO3)(H2O)(3)](3-) based on a hexadentate hydroxyquinoline ligand shows high thermodynamic stability and high relaxivity (12.54 mM(-1) s(-1) at 1.2 T). Its non-covalent confinement in 25 nm silica nanoparticles prevents transmetallation and endogenous anion binding and leads to higher relaxivity over a wide range of magnetic fields.

引用

页码：6836 / 6838

页数：3

共 18 条

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