Multi-Enzymatic Cascade Reactions: Overview and Perspectives

被引：412
作者：
Ricca, Emanuele [2 ]
Brucher, Birgit [3 ]
Schrittwieser, Joerg H. [1 ]
机构：
[1] Graz Univ, Dept Chem Organ & Bioorgan Chem, A-8010 Graz, Austria
[2] Univ Calabria, Fac Engn, Lab Transport Phenomena & Biotechnol, I-87036 Arcavacata Di Rende, CS, Italy
[3] Arlsruhe Inst Technol, Inst Proc Engn Life Sci, Sect Tech Biol 2, D-76131 Karlsruhe, Germany
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 13期
关键词：
alcohols; amines; biocatalysis; cascade reactions; C-C coupling; D-AMINO ACIDS; N-ACETYLNEURAMINIC ACID; ALPHA-KETO ACIDS; SIMULTANEOUS NAD(H) REGENERATION; OPTICALLY-ACTIVE AMINES; ESCHERICHIA-COLI-CELLS; D-XYLULOSE; 5-PHOSPHATE; IN-SITU GENERATION; ONE-STEP SYNTHESIS; ONE-POT SYNTHESIS;
D O I：
10.1002/adsc.201100256
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Multi-enzymatic cascade reactions, i.e., the combination of several enzymatic transformations in concurrent one-pot processes, offer considerable advantages: the demand of time, costs and chemicals for product recovery may be reduced, reversible reactions can be driven to completion and the concentration of harmful or unstable compounds can be kept to a minimum. This review summarizes the developments in multi-enzymatic cascades employed for the asymmetric synthesis of chiral alcohols, amines and amino acids, as well as for C-C bond formation. In addition, a general classification of biocatalytic cascade systems is provided and bioprocess engineering aspects associated with the topic are discussed.
引用
收藏
页码：2239 / 2262
页数：24
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