Plasma Cytokines Profile in Patients with Parkinson's Disease Associated with Mutations in GBA Gene

被引：28

作者：

Miliukhina, I. V. ^{[1
,2
,3
]}

Usenko, T. S. ^{[2
,3
]}

Senkevich, K. A. ^{[1
,2
,3
]}

Nikolaev, M. A. ^{[2
,3
]}

Timofeeva, A. A. ^{[2
]}

Agapova, E. A. ^{[3
]}

Semenov, A. V. ^{[2
,4
]}

Lubimova, N. E. ^{[4
]}

Totolyan, A. A. ^{[2
,4
]}

Pchelina, S. N. ^{[1
,2
,3
]}

机构：

[1] Inst Expt Med, Gatchina, Leningrad Regio, Russia

[2] IP Pavlov First St Petersburg State Med Univ, Minist Hlth Russian Federat, Gatchina, Leningrad Regio, Russia

[3] Kurchatov Inst, Natl Res Ctr, BP Konstantinov St Petersburg Nucl Phys Inst, Gatchina, Leningrad Regio, Russia

[4] Pasteur St Petersburg Res Inst Epidemiol & Microb, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 168卷 / 04期

关键词：

Parkinson's disease; neuroinflammation; GBA mutation; cytokines; ELISA and multiplex assays; INFLAMMATORY CYTOKINES; BLOOD;

D O I：

10.1007/s10517-020-04723-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Plasma cytokine concentration in patients with Parkinson's disease and mutation in GBA gene, in patients with sporadic Parkinson's disease, and in healthy volunteers were measured by ELISA and multiplex analysis. In patients with Parkinson's disease and mutation in GBA gene, elevated plasma concentrations of IL-1 beta and TNF alpha were revealed by ELISA in comparison with both controls and patients with sporadic form of Parkinson's disease. Multiplex analysis revealed enhanced secretion of IL-1 beta, IL-2, IFN gamma and reduced plasma levels of monocyte chemoattractant protein-1 (MCP-1) in patients with Parkinson's disease and mutation in GBA gene (in comparison with other groups) and increased plasma levels of IL-13 (only in comparison with the healthy volunteers). Our results support the hypothesis that the concentrations of inflammatory mediators are increased in patients with Parkinson's disease and mutation in GBA gene.

引用

页码：423 / 426

页数：4

共 12 条

[1] Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs Without GBA Mutations [J].

Chahine, Lama M. ;

Qiang, Judy ;

Ashbridge, Emily ;

Minger, James ;

Yearout, Dora ;

Horn, Stacy ;

Colcher, Amy ;

Hurtig, Howard I. ;

Lee, Virginia M-Y. ;

Van Deerlin, Vivianna M. ;

Leverenz, James B. ;

Siderowf, Andrew D. ;

Trojanowski, John Q. ;

Zabetian, Cyrus P. ;

Chen-Plotkin, Alice .

JAMA NEUROLOGY, 2013, 70 (07) :852-858

[2] Mutation analysis of Parkinson's disease genes in a Russian data set [J].

Emelyanov, Anton K. ;

Usenko, Tatiana S. ;

Tesson, Christelle ;

Senkevich, Konstantin A. ;

Nikolaev, Mikhail A. ;

Miliukhina, Irina V. ;

Kopytova, Alena E. ;

Timofeeva, Alla A. ;

Yakimovsky, Andrey F. ;

Lesage, Suzanne ;

Brice, Alexis ;

Pchelina, Sofya N. .

NEUROBIOLOGY OF AGING, 2018, 71 :267.e7-267.e10

[3] Elevated Alpha-Synuclein Impairs Innate Immune Cell Function and Provides a Potential Peripheral Biomarker for Parkinson's Disease [J].

Gardai, Shyra J. ;

Mao, Wenxian ;

Schuele, Birgitt ;

Babcock, Michael ;

Schoebel, Sue ;

Lorenzana, Carlos ;

Alexander, Jeff ;

Kim, Sam ;

Glick, Heather ;

Hilton, Kathryn ;

Fitzgerald, J. Kent ;

Buttini, Manuel ;

Chiou, San-San ;

McConlogue, Lisa ;

Anderson, John P. ;

Schenk, Dale B. ;

Bard, Frederique ;

Langston, J. William ;

Yednock, Ted ;

Johnston, Jennifer A. .

PLOS ONE, 2013, 8 (08)

[4] A low blood copper concentration is a co-morbidity burden factor in Parkinson's disease development [J].

Ilyechova, Ekaterina Y. ;

Miliukhin, Irina, V ;

Orlov, Iurii A. ;

Muruzheva, Zamira M. ;

Puchkova, Ludmila, V ;

Karpenko, Marina N. .

NEUROSCIENCE RESEARCH, 2018, 135 :54-62

[5] Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-α levels in CSF and serum in relation to the clinical diversity of Parkinson's disease [J].

Karpenko, M. N. ;

Vasilishina, A. A. ;

Gromova, E. A. ;

Muruzheva, Z. M. ;

Bernadotte, A. .

CELLULAR IMMUNOLOGY, 2018, 327 :77-82

[6] Inflammatory cytokines and NT-proCNP in Parkinson's disease patients [J].

Koziorowski, Dariusz ;

Tomasiuk, Ryszard ;

Szlufik, Stanislaw ;

Friedman, Andrzej .

CYTOKINE, 2012, 60 (03) :762-766

[7]

Milyukhina I V, 2015, Klin Med (Mosk), V93, P51

[8] MDS clinical diagnostic criteria for Parkinson's disease [J].

Postuma, Ronald B. ;

Berg, Daniela ;

Stern, Matthew ;

Poewe, Werner ;

Olanow, C. Warren ;

Oertel, Wolfgang ;

Obeso, Jose ;

Marek, Kenneth ;

Litvan, Irene ;

Lang, Anthony E. ;

Halliday, Glenda ;

Goetz, Christopher G. ;

Gasser, Thomas ;

Dubois, Bruno ;

Chan, Piu ;

Bloem, Bastiaan R. ;

Adler, Charles H. ;

Deuschl, Guenther .

MOVEMENT DISORDERS, 2015, 30 (12) :1591-1599

[9] Brain Injection of α-Synuclein Induces Multiple Proteinopathies, Gliosis, and a Neuronal Injury Marker [J].

Sacino, Amanda N. ;

Brooks, Mieu ;

McKinney, Alex B. ;

Thomas, Michael A. ;

Shaw, Gerry ;

Golde, Todd E. ;

Giasson, Benoit I. .

JOURNAL OF NEUROSCIENCE, 2014, 34 (37) :12368-12378

[10]

Senkevich K A, 2017, Zh Nevrol Psikhiatr Im S S Korsakova, V117, P81, DOI 10.17116/jnevro201711710181-86

← 1 2 →