IL-6 signaling in diabetic nephropathy: From pathophysiology to therapeutic perspectives

被引：90
作者：
Feigerlova, Eva [1 ,2 ,3 ,4 ]
Battaglia-Hsu, Shyue-Fang [5 ,6 ]
机构：
[1] CHU Poitiers, Serv Endocrinol, Pole DUNE, Poitiers, France
[2] Univ Poitiers, UFR Med Pharm, Poitiers, France
[3] Univ Poitiers, INSERM, CIC 1402, Poitiers, France
[4] Univ Poitiers, U1082, Poitiers, France
[5] Univ Lorraine, INSERM, Nutr Genet & Exposit Risques Environm U954, Med Fac, Vandoeuvre Les Nancy, France
[6] Reg Univ Hosp Ctr Nancy, Vandoeuvre Les Nancy, France
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2017年 / 37卷
关键词：
IL-6; signaling; Trans-signaling; Immunoregulation; Diabetic nephropathy; RHEUMATOID-ARTHRITIS; INTERLEUKIN-6; FAMILY; TRANSDUCER GP130; SOLUBLE IL-6R; CUTTING EDGE; RECEPTOR; STAT3; INHIBITOR; CYTOKINE; INFLAMMATION;
D O I：
10.1016/j.cytogfr.2017.03.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD). Interleukin-6 (IL-6) signaling participates in inflammation responses central to the progression of DN. Current evidence suggests that these IL-6 responses are mediated via gp130-STAT3 dependent mechanisms which, on one hand, trigger globally the transition from innate to adaptive immune response, and on the other hand act locally for tissue remodeling and immune cell infiltration. In diabetic conditions the role of IL-6 is not well elucidated. Both IL-6 classical signaling pathway via receptor IL-6R (IL-6R) and IL-6 trans-signaling pathway via soluble IL-6R (sIL-6R) were shown to participate in the pathogenesis and progression of DN, and IL-6 appears to influence renal cells also in an autocrine manner. To date, evidence is limited. The goal of this review is to provide an overview of our current understanding on the role of IL-6 signaling in DN and to delineate challenges for future research. Putative sequential events related to IL-6 secretion by different cell populations in diabetic conditions are outlined. Further, we discuss potential applications of anti-IL-6 therapy in the context of DN. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：57 / 65
页数：9
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