Effect of repetitive transcranial magnetic stimulation on auditory function following acoustic trauma

被引：4
作者：
Yang, Haidi [1 ,2 ]
Xiong, Hao [1 ,2 ]
Ou, Yongkang [1 ,2 ]
Xu, Yaodong [1 ,2 ]
Pang, Jiaqi [1 ,2 ]
Lai, Lan [1 ,2 ]
Zheng, Yiqing [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Otolaryngol, 107 West Yan Jiang Rd, Guangzhou 510120, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Inst Hearing & Speech Language Sci, Guangzhou, Guangdong, Peoples R China
来源：
NEUROLOGICAL SCIENCES | 2016年 / 37卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Acoustic trauma; Auditory cortex; Brain-derived neurotrophic factor; Repetitive transcranial magnetic stimulation; Tinnitus; HEARING-LOSS; TINNITUS PERCEPTION; NEUROTROPHIC FACTOR; EXPRESSION; PLASTICITY; CORTEX; MODEL; BDNF; APOPTOSIS; MICE;
D O I：
10.1007/s10072-016-2603-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Repetitive transcranial magnetic stimulation (rTMS) is one form of non-invasive brain stimulation and increasingly shows neuroprotection in multiple neurological disorders. However, the potential of rTMS for protective action on auditory function following acoustic trauma has not been investigated. Here, we examined effect of TMS on hearing conservation, neurons survival and brain-derived neurotrophin factor (BDNF) expression in the cochlea and auditory cortex following acoustic trauma in rats. Wistar rats were exposed to intense pure tone noise (10 kHz, 120 dB SPL for 2 h) followed by rTMS treatment or sham treatment (handling control) daily for 14 days. Auditory brainstem response revealed there was no significant difference in hearing threshold shifts between rTMS- and sham-treated rats, although rTMS-treated rats showed less neuron loss in the auditory cortex in comparison with sham rats. Additionally, acoustic trauma increased BDNF expression in the cochlea and auditory cortex, and this elevation could be attenuated by rTMS treatment. Our results suggest present regiment of rTMS does not protect hearing against acoustic trauma, but maybe have implications for tinnitus treatment.
引用
收藏
页码：1511 / 1516
页数：6
相关论文
共 31 条
  • [1] [Anonymous], COCHRANE DATABASE SY
  • [2] Central gain control in tinnitus and hyperacusis
    Auerbach, Benjamin D.
    Rodrigues, Paulo V.
    Salvi, Richard J.
    [J]. FRONTIERS IN NEUROLOGY, 2014, 5
  • [3] Tinnitus
    Baguley, David
    McFerran, Don
    Hall, Deborah
    [J]. LANCET, 2013, 382 (9904) : 1600 - 1607
  • [4] Noise-induced cell death in the mouse medial geniculate body and primary auditory cortex
    Basta, D
    Tzschentke, B
    Ernst, A
    [J]. NEUROSCIENCE LETTERS, 2005, 381 (1-2) : 199 - 204
  • [5] Cochlear NMDA Receptors as a Therapeutic Target of Noise-Induced Tinnitus
    Bing, Dan
    Lee, Sze Chim
    Campanelli, Dario
    Xiong, Hao
    Matsumoto, Masahiro
    Panford-Walsh, Rama
    Wolpert, Stephan
    Praetorius, Mark
    Zimmermann, Ulrike
    Chu, Hanqi
    Knipper, Marlies
    Ruettiger, Lukas
    Singer, Wibke
    [J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2015, 35 (05) : 1905 - 1923
  • [6] Long-lasting effects of high frequency repetitive transcranial magnetic stimulation in major depressed patients
    Bortolomasi, Marco
    Minelli, Alessandra
    Fuggetta, Giorgio
    Perini, Michele
    Comencini, Sandra
    Fiaschi, Antonio
    Manganotti, Paolo
    [J]. PSYCHIATRY RESEARCH, 2007, 150 (02) : 181 - 186
  • [7] Apoptotic Cascades in the Central Auditory Pathway after Noise Exposure
    Coordes, Annekatrin
    Groeschel, Moritz
    Ernst, Arne
    Basta, Dietmar
    [J]. JOURNAL OF NEUROTRAUMA, 2012, 29 (06) : 1249 - 1254
  • [8] Restoring Synaptic Connections in the Inner Ear after Noise Damage
    Cunningham, Lisa L.
    Tucci, Debara L.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (02) : 181 - 182
  • [9] Apoptosis in acquired and genetic hearing impairment: The programmed death of the hair cell
    de Beeck, Ken Op
    Schacht, Jochen
    Van Camp, Guy
    [J]. HEARING RESEARCH, 2011, 281 (1-2) : 18 - 27
  • [10] Magnetic and electrical stimulation of the auditory cortex for intractable tinnitus - Case report
    De Ridder, D
    De Mulder, G
    Walsh, V
    Muggleton, N
    Sunaert, S
    Moller, A
    [J]. JOURNAL OF NEUROSURGERY, 2004, 100 (03) : 560 - 564
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