Genomic heterogeneity of multiple synchronous lung cancer

被引：183

作者：

Liu, Yu ^{[1
,2
]}

Zhang, Jianjun ^{[3
,4
]}

Li, Lin ^{[1
,2
,5
,6
]}

Yin, Guangliang ^{[6
]}

Zhang, Jianhua ^{[7
]}

Zheng, Shan ^{[2
,5
]}

Cheung, Hannah ^{[3
]}

Wu, Ning ^{[2
,8
]}

Lu, Ning ^{[2
,5
]}

Mao, Xizeng ^{[7
]}

Yang, Longhai ^{[2
,9
]}

Zhang, Jiexin ^{[10
]}

Zhang, Li ^{[2
,8
]}

Seth, Sahil ^{[7
]}

Chen, Huang ^{[1
,2
]}

Song, Xingzhi ^{[7
]}

Liu, Kan ^{[2
,8
]}

Xie, Yongqiang ^{[2
,5
]}

Zhou, Lina ^{[2
,8
]}

Zhao, Chuanduo ^{[2
,9
]}

Han, Naijun ^{[1
,2
]}

Chen, Wenting ^{[1
,2
]}

Zhang, Susu ^{[1
,2
]}

Chen, Longyun ^{[6
]}

Cai, Wenjun ^{[6
]}

Li, Lin ^{[1
,2
,5
,6
]}

Shen, Miaozhong ^{[6
]}

Xu, Ningzhi ^{[11
]}

Cheng, Shujun ^{[1
,2
]}

Yang, Huanming ^{[6
]}

Lee, J. Jack ^{[12
]}

Correa, Arlene ^{[13
]}

Fujimoto, Junya ^{[14
]}

Behrens, Carmen ^{[14
]}

Chow, Chi-Wan ^{[14
]}

William, William N. ^{[4
]}

Heymach, John V. ^{[4
]}

Hong, Waun Ki ^{[4
]}

Swisher, Stephen ^{[13
]}

Wistuba, Ignacio I. ^{[14
]}

Wang, Jun ^{[6
,15
]}

Lin, Dongmei ^{[2
,5
]}

Liu, Xiangyang ^{[2
,9
]}

Futreal, P. Andrew ^{[3
,16
]}

Gao, Yanning ^{[1
,2
]}

机构：

[1] Peking Union Med Coll, State Key Lab Mol Oncol, Dept Etiol & Carcinogenesis, Canc Inst & Hosp, Beijing 100021, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100021, Peoples R China

[3] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, 1515 Holcombe Blvd, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, 1515 Holcombe Blvd, Houston, TX 77030 USA

[5] Peking Union Med Coll, Canc Inst & Hosp, Dept Pathol, Beijing 100021, Peoples R China

[6] Beijing Genom Inst, Shenzhen 518083, Peoples R China

[7] Univ Texas MD Anderson Canc Ctr, Inst Appl Canc Sci, 1515 Holcombe Blvd, Houston, TX 77030 USA

[8] Peking Union Med Coll, Canc Inst & Hosp, Dept Diagnost Imaging, Beijing 100021, Peoples R China

[9] Peking Union Med Coll, Canc Inst & Hosp, Dept Thorac Surg Oncol, Beijing 100021, Peoples R China

[10] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, 1515 Holcombe Blvd, Houston, TX 77030 USA

[11] Peking Union Med Coll, Canc Inst & Hosp, Dept Cellular & Mol Biol, State Key Lab Mol Oncol, Beijing 100021, Peoples R China

[12] Univ Texas MD Anderson Canc Ctr, Dept Biostat, 1515 Holcombe Blvd, Houston, TX 77030 USA

[13] Univ Texas MD Anderson Canc Ctr, Dept Thorac & Cardiovasc Surg, 1515 Holcombe Blvd, Houston, TX 77030 USA

[14] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, 1515 Holcombe Blvd, Houston, TX 77030 USA

[15] Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark

[16] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

中国国家自然科学基金;

关键词：

SOMATIC MUTATIONS; CELL CARCINOMAS; TUMORS; PATTERNS; CLASSIFICATION; INSTABILITY; MUTAGENESIS; METASTASES; DISCOVERY; FRAMEWORK;

D O I：

10.1038/ncomms13200

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC. All 15 lung tumours demonstrate distinct genomic profiles, suggesting all are independent primary tumours, which are consistent with comprehensive histopathological assessment in 5 of the 6 patients. Lung tumours of the same individuals are no more similar to each other than are lung adenocarcinomas of different patients from TCGA cohort matched for tumour size and smoking status. Several known cancer-associated genes have different mutations in different tumours from the same patients. These findings suggest that in the context of identical constitutional genetic background and environmental exposure, different lung cancers in the same individual may have distinct genomic profiles and can be driven by distinct molecular events.

引用

页数：8

共 44 条

[1] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[2] Evidence for APOBEC3B mutagenesis in multiple human cancers [J].

Burns, Michael B. ;

Temiz, Nuri A. ;

Harris, Reuben S. .

NATURE GENETICS, 2013, 45 (09) :977-+

[3] The patterns and dynamics of genomic instability in metastatic pancreatic cancer [J].

Campbell, Peter J. ;

Yachida, Shinichi ;

Mudie, Laura J. ;

Stephens, Philip J. ;

Pleasance, Erin D. ;

Stebbings, Lucy A. ;

Morsberger, Laura A. ;

Latimer, Calli ;

McLaren, Stuart ;

Lin, Meng-Lay ;

McBride, David J. ;

Varela, Ignacio ;

Nik-Zainal, Serena A. ;

Leroy, Catherine ;

Jia, Mingming ;

Menzies, Andrew ;

Butler, Adam P. ;

Teague, Jon W. ;

Griffin, Constance A. ;

Burton, John ;

Swerdlow, Harold ;

Quail, Michael A. ;

Stratton, Michael R. ;

Iacobuzio-Donahue, Christine ;

Futreal, P. Andrew .

NATURE, 2010, 467 (7319) :1109-1113

[4] Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples [J].

Cibulskis, Kristian ;

Lawrence, Michael S. ;

Carter, Scott L. ;

Sivachenko, Andrey ;

Jaffe, David ;

Sougnez, Carrie ;

Gabriel, Stacey ;

Meyerson, Matthew ;

Lander, Eric S. ;

Getz, Gad .

NATURE BIOTECHNOLOGY, 2013, 31 (03) :213-219

[5] Comprehensive molecular profiling of lung adenocarcinoma [J].

Collisson, Eric A. ;

Campbell, Joshua D. ;

Brooks, Angela N. ;

Berger, Alice H. ;

Lee, William ;

Chmielecki, Juliann ;

Beer, David G. ;

Cope, Leslie ;

Creighton, Chad J. ;

Danilova, Ludmila ;

Ding, Li ;

Getz, Gad ;

Hammerman, Peter S. ;

Hayes, D. Neil ;

Hernandez, Bryan ;

Herman, James G. ;

Heymach, John V. ;

Jurisica, Igor ;

Kucherlapati, Raju ;

Kwiatkowski, David ;

Ladanyi, Marc ;

Robertson, Gordon ;

Schultz, Nikolaus ;

Shen, Ronglai ;

Sinha, Rileen ;

Sougnez, Carrie ;

Tsao, Ming-Sound ;

Travis, William D. ;

Weinstein, John N. ;

Wigle, Dennis A. ;

Wilkerson, Matthew D. ;

Chu, Andy ;

Cherniack, Andrew D. ;

Hadjipanayis, Angela ;

Rosenberg, Mara ;

Weisenberger, Daniel J. ;

Laird, Peter W. ;

Radenbaugh, Amie ;

Ma, Singer ;

Stuart, Joshua M. ;

Byers, Lauren Averett ;

Baylin, Stephen B. ;

Govindan, Ramaswamy ;

Meyerson, Matthew ;

Rosenberg, Mara ;

Gabriel, Stacey B. ;

Cibulskis, Kristian ;

Sougnez, Carrie ;

Kim, Jaegil ;

Stewart, Chip .

NATURE, 2014, 511 (7511) :543-550

[6] Spatial and temporal diversity in genomic instability processes defines lung cancer evolution [J].

de Bruin, Elza C. ;

McGranahan, Nicholas ;

Mitter, Richard ;

Salm, Max ;

Wedge, David C. ;

Yates, Lucy ;

Jamal-Hanjani, Mariam ;

Shafi, Seema ;

Murugaesu, Nirupa ;

Rowan, Andrew J. ;

Groenroos, Eva ;

Muhammad, Madiha A. ;

Horswell, Stuart ;

Gerlinger, Marco ;

Varela, Ignacio ;

Jones, David ;

Marshall, John ;

Voet, Thierry ;

Van Loo, Peter ;

Rassl, Doris M. ;

Rintoul, Robert C. ;

Janes, Sam M. ;

Lee, Siow-Ming ;

Forster, Martin ;

Ahmad, Tanya ;

Lawrence, David ;

Falzon, Mary ;

Capitanio, Arrigo ;

Harkins, Timothy T. ;

Lee, Clarence C. ;

Tom, Warren ;

Teefe, Enock ;

Chen, Shann-Ching ;

Begum, Sharmin ;

Rabinowitz, Adam ;

Phillimore, Benjamin ;

Spencer-Dene, Bradley ;

Stamp, Gordon ;

Szallasi, Zoltan ;

Matthews, Nik ;

Stewart, Aengus ;

Campbell, Peter ;

Swanton, Charles .

SCIENCE, 2014, 346 (6206) :251-256

[7] A framework for variation discovery and genotyping using next-generation DNA sequencing data [J].

DePristo, Mark A. ;

Banks, Eric ;

Poplin, Ryan ;

Garimella, Kiran V. ;

Maguire, Jared R. ;

Hartl, Christopher ;

Philippakis, Anthony A. ;

del Angel, Guillermo ;

Rivas, Manuel A. ;

Hanna, Matt ;

McKenna, Aaron ;

Fennell, Tim J. ;

Kernytsky, Andrew M. ;

Sivachenko, Andrey Y. ;

Cibulskis, Kristian ;

Gabriel, Stacey B. ;

Altshuler, David ;

Daly, Mark J. .

NATURE GENETICS, 2011, 43 (05) :491-+

[8]

DESLAURIERS J, 1989, J THORAC CARDIOV SUR, V97, P504

[9] The IASLC Lung Cancer Staging Project: Background Data and Proposed Criteria to Distinguish Separate Primary Lung Cancers from Metastatic Foci in Patients with Two Lung Tumors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer [J].

Detterbeck, Frank C. ;

Franklin, Wilbur A. ;

Nicholson, Andrew G. ;

Girard, Nicolas ;

Arenberg, Douglas A. ;

Travis, William D. ;

Mazzone, Peter J. ;

Marom, Edith M. ;

Donington, Jessica S. ;

Tanoue, Lynn T. ;

Rusch, Valerie W. ;

Asamura, Hisao ;

Rami-Porta, Ramon .

JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (05) :651-665

[10] Somatic mutations affect key pathways in lung adenocarcinoma [J].

Ding, Li ;

Getz, Gad ;

Wheeler, David A. ;

Mardis, Elaine R. ;

McLellan, Michael D. ;

Cibulskis, Kristian ;

Sougnez, Carrie ;

Greulich, Heidi ;

Muzny, Donna M. ;

Morgan, Margaret B. ;

Fulton, Lucinda ;

Fulton, Robert S. ;

Zhang, Qunyuan ;

Wendl, Michael C. ;

Lawrence, Michael S. ;

Larson, David E. ;

Chen, Ken ;

Dooling, David J. ;

Sabo, Aniko ;

Hawes, Alicia C. ;

Shen, Hua ;

Jhangiani, Shalini N. ;

Lewis, Lora R. ;

Hall, Otis ;

Zhu, Yiming ;

Mathew, Tittu ;

Ren, Yanru ;

Yao, Jiqiang ;

Scherer, Steven E. ;

Clerc, Kerstin ;

Metcalf, Ginger A. ;

Ng, Brian ;

Milosavljevic, Aleksandar ;

Gonzalez-Garay, Manuel L. ;

Osborne, John R. ;

Meyer, Rick ;

Shi, Xiaoqi ;

Tang, Yuzhu ;

Koboldt, Daniel C. ;

Lin, Ling ;

Abbott, Rachel ;

Miner, Tracie L. ;

Pohl, Craig ;

Fewell, Ginger ;

Haipek, Carrie ;

Schmidt, Heather ;

Dunford-Shore, Brian H. ;

Kraja, Aldi ;

Crosby, Seth D. ;

Sawyer, Christopher S. .

NATURE, 2008, 455 (7216) :1069-1075

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