Foxo in the immune system

被引：92
作者：
Peng, S. L. [1 ]
机构：
[1] Clin Res & Exploratory Dev, Palo Alto, CA 94304 USA
来源：
ONCOGENE | 2008年 / 27卷 / 16期
关键词：
transcription factors; autoimmunity; T cells; B cells; arthritis; lupus;
D O I：
10.1038/onc.2008.26
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In addition to their key roles in cellular survival, death, proliferation and metabolism, the Foxo subfamily of forkhead (Fox) transcription factors play critical roles in the homeostasis of immune-relevant cells, including T cells, B cells, neutrophils and other non-lymphoid lineages that modulate inflammation in disease states such as inflammatory arthritis and systemic lupus erythematosus. This review summarizes such current and expanding knowledge of the Foxo family members in immunity, and their potential as therapeutic targets in inflammatory disease.
引用
收藏
页码：2337 / 2344
页数：8
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