Brain Natriuretic Peptide Levels in Pediatric Cancer Patients with Febrile Neutropenia

被引：3

作者：

Bayram, Ibrahim ^{[1
]}

Erbey, Fatih ^{[1
]}

Erdem, Sevcan ^{[2
]}

Tanyeli, Atila ^{[1
]}

机构：

[1] Cukurova Univ, Fac Med, Dept Pediat Oncol, Adana, Turkey

[2] Cukurova Univ, Fac Med, Dept Pediat Cardiol, Adana, Turkey

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2011年 / 28卷 / 04期

关键词：

brain natriuretic peptide; childhood; febrile neutropenia; malignant disease; LEFT-VENTRICULAR DYSFUNCTION; SEPTIC SHOCK; SEVERE SEPSIS; MYOCARDIAL DEPRESSION; ACTIVATION; OVERLOAD; IMPACT;

D O I：

10.3109/08880018.2010.548849

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Brain natriuretic peptide (BNP) is considered as a prognostic marker in patients with sepsis, but no data are available on BNP in pediatric cancer patients with febrile neutropenia (FN). Twenty-five pediatric cancer patients with FN were included in this study. Serum BNP level was measured. The mean BNP level was 330.8 +/- 765.3 pg/mL (5.9-3806 pg/mL). BNP levels of 12 patients were found over the normal level. High BNP levels were related to some conditions of the patients, and these were statistically significant (P < .05). These conditions were required erythrocyte suspension, had pneumonia, time stayed in hospital, and neutropenia time. When regression test was done, required erythrocyte suspension for anemia and had pneumonia were found to be statistically significant. In conclusion, this is one of the first studies on BNP levels in pediatric cancer patients with FN. However, further studies with large sample sizes are needed to confirm the results and provide new data about this issue.

引用

页码：294 / 298

页数：5

共 20 条

[1] Prognostic value of plasma N-terminal pro-brain natriuretic peptide in patients with severe sepsis [J].

Brueckmann, M ;

Huhle, G ;

Lang, S ;

Haase, KK ;

Bertsch, T ;

Weiss, C ;

Kaden, JJ ;

Putensen, C ;

Borggrefe, M ;

Hoffmann, U .

CIRCULATION, 2005, 112 (04) :527-534

[2] Cancer patients with markedly elevated B-type natriuretic peptide may not have volume overload [J].

Burjonroppa, Sukesh C. ;

Tong, Ann T. ;

Xiao, Lian-Chun ;

Johnson, Marcella M. ;

Yusuf, S. Wamique ;

Lenihan, Daniel J. .

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, 2007, 30 (03) :287-293

[3] Brain natriuretic peptide: a potential marker for mortality in septic shock [J].

Castillo, JR ;

Zagler, A ;

Carrillo-Jimenez, R ;

Hennekens, CH .

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2004, 8 (05) :271-274

[4] Clinical review: Myocardial depression in sepsis and septic shock [J].

Court, O ;

Kumar, A ;

Parrillo, JE ;

Kumar, A .

CRITICAL CARE, 2002, 6 (06) :500-508

[5] COMPARISON OF NEUROENDOCRINE ACTIVATION IN PATIENTS WITH LEFT-VENTRICULAR DYSFUNCTION WITH AND WITHOUT CONGESTIVE-HEART-FAILURE - A SUBSTUDY OF THE STUDIES OF LEFT-VENTRICULAR DYSFUNCTION (SOLVD) [J].

FRANCIS, GS ;

BENEDICT, C ;

JOHNSTONE, DE ;

KIRLIN, PC ;

NICKLAS, J ;

LIANG, CS ;

KUBO, SH ;

RUDINTORETSKY, E ;

YUSUF, S .

CIRCULATION, 1990, 82 (05) :1724-1729

[6] Serum amino-terminal pro-brain natriuretic peptide in hematological patients with neutropenic fever: a prospective comparison with C-reactive protein [J].

Hamalainen, Sari ;

Juutilainen, Auni ;

Kuittinen, Taru ;

Nousiainen, Tapio ;

Matinlauri, Irma ;

Pulkki, Kari ;

Koivula, Irma ;

Jantunen, Esa .

LEUKEMIA & LYMPHOMA, 2010, 51 (06) :1040-1046

[7] 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer [J].

Hughes, WT ;

Armstrong, D ;

Bodey, GP ;

Bow, EJ ;

Brown, AE ;

Calandra, T ;

Feld, R ;

Pizzo, PA ;

Rolston, KVI ;

Shenep, JL ;

Young, LS .

CLINICAL INFECTIOUS DISEASES, 2002, 34 (06) :730-751

[8] PROGNOSTIC IMPORTANCE OF INCREASED PLASMA AMINO-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE LEVELS IN A LARGE NONCARDIAC, GENERAL INTENSIVE CARE UNIT POPULATION [J].

Kotanidou, Anastasia ;

Karsaliakos, Petros ;

Tzanela, Marinella ;

Mavrou, Irini ;

Kopterides, Petros ;

Papadomichelakis, Evangelos ;

Theodorakopoulou, Maria ;

Botoula, Efi ;

Tsangaris, Iralklis ;

Lignos, Michalis ;

Ikonomidis, Ignatios ;

Ilias, Ioannis ;

Armaganidis, Apostolos ;

Ortanos, Stylianos E. ;

Dimopoulou, Ioanna .

SHOCK, 2009, 31 (04) :342-347

[9] Septic myocardial depression: No "no" to NO? [J].

Kumar, A ;

Osman, J .

CRITICAL CARE MEDICINE, 2001, 29 (01) :202-203

[10]

Levin ER, 1998, NEW ENGL J MED, V339, P321

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