Activity of Cefiderocol and Comparators against Isolates from Cancer Patients

被引：51

作者：

Rolston, Kenneth V. I. ^{[1
]}

Gerges, Baghat ^{[1
]}

Shelburne, Samuel ^{[1
]}

Aitken, Samuel L. ^{[2
]}

Raad, Issam ^{[1
]}

Prince, Randall A. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Infect Dis Infect Control & Employee Hlth, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Div Pharm, Houston, TX 77030 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2020年 / 64卷 / 05期

关键词：

Gram-negative isolates; Pseudomonas aeruginosa; Stenotrophomonas maltophilia; cefiderocol; VITRO ANTIMICROBIAL ACTIVITY; SIDEROPHORE CEPHALOSPORIN; S-649266;

D O I：

10.1128/AAC.01955-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cefiderocol inhibited 97.5% of 478 Gram-negative isolates from cancer patients at <= 4 mg/liter. It had potent activity against extended-spectrum beta-lactamase-positive Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae (CRE), and nonfermenting Gram-negative bacilli, including Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter species isolates. Amikacin, ceftazidime-avibactam, and meropenem had appreciable activity against non-CRE Enterobacteriaceae. No comparators were active against multidrug-resistant P. aeruginosa isolates. Only trimethoprim-sulfamethoxazole had appreciable activity against S. maltophilia isolates. Overall, cefiderocol was associated with the lowest level of resistance.

引用

页数：7

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