More Than the Sum of Its Parts: Single-Cell Transcriptomics Reveals Epidermal Cell States

被引:3
|
作者
Mok, Ka-Wai [1 ]
Saxena, Nivedita [1 ,2 ]
Rendl, Michael [1 ,2 ]
机构
[1] Icahn Sch Med Mt Sinai, Dept Dermatol, Dept Cell Dev & Regenerat Biol, Black Family Stem Cell Inst, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, Grad Sch Biomed Sci, New York, NY 10029 USA
来源
CELL REPORTS | 2018年 / 25卷 / 04期
关键词
STEM-CELLS; SKIN;
D O I
10.1016/j.celrep.2018.10.041
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Compared to mouse models, less is known about human epidermal cell states and differentiation. In this issue of Cell Reports, Cheng et al. (2018) dissect the cell states and heterogeneity in human epidermis with large-scale transcriptomics of 92,889 single epidermal cells from normal and inflamed skin.
引用
收藏
页码:823 / 824
页数:2
相关论文
共 50 条
  • [1] Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity
    Joost, Simon
    Zeisel, Amit
    Jacob, Tina
    Sun, Xiaoyan
    La Manno, Gioele
    Lonnerberg, Peter
    Linnarsson, Sten
    Kasper, Maria
    CELL SYSTEMS, 2016, 3 (03) : 221 - +
  • [2] Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics
    Haensel, Daniel
    Jin, Suoqin
    Sun, Peng
    Cinco, Rachel
    Dragan, Morgan
    Quy Nguyen
    Cang, Zixuan
    Gong, Yanwen
    Vu, Remy
    MacLean, Adam L.
    Kessenbrock, Kai
    Gratton, Enrico
    Nie, Qing
    Dai, Xing
    CELL REPORTS, 2020, 30 (11): : 3932 - +
  • [3] Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations
    Hao, Zhao-Zhe
    Wei, Jia-Ru
    Xiao, Dongchang
    Liu, Ruifeng
    Xu, Nana
    Tang, Lei
    Huang, Mengyao
    Shen, Yuhui
    Xing, Changsheng
    Huang, Wanjing
    Liu, Xialin
    Xiang, Mengqing
    Liu, Yizhi
    Miao, Zhichao
    Liu, Sheng
    NATURE NEUROSCIENCE, 2022, 25 (06) : 805 - +
  • [4] Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover of Keratinocyte Differentiation Regulators
    Finnegan, Alex
    Cho, Raymond J.
    Luu, Alan
    Harirchian, Paymann
    Lee, Jerry
    Cheng, Jeffrey B.
    Song, Jun S.
    FRONTIERS IN GENETICS, 2019, 10
  • [5] Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma
    Xiong, Gan
    Xie, Nan
    Nie, Min
    Ling, Rongsong
    Yun, Bokai
    Xie, Jiaxiang
    Ren, Linlin
    Huang, Yaqi
    Wang, Wenjin
    Yi, Chen
    Zhang, Ming
    Xu, Xiuyun
    Zhang, Caihua
    Zou, Bin
    Zhang, Leitao
    Liu, Xiqiang
    Huang, Hongzhang
    Chen, Demeng
    Cao, Wei
    Wang, Cheng
    INTERNATIONAL JOURNAL OF ORAL SCIENCE, 2024, 16 (01)
  • [6] Single-cell transcriptomics reveals the cell fate transitions of human dopaminergic progenitors derived from hESCs
    Liang, Lingmin
    Tian, Yao
    Feng, Lin
    Wang, Chaoqun
    Feng, Guihai
    Stacey, Glyn Nigel
    Shyh-Chang, Ng
    Wu, Jun
    Hu, Baoyang
    Li, Wei
    Hao, Jie
    Wang, Liu
    Wang, Yukai
    STEM CELL RESEARCH & THERAPY, 2022, 13 (01)
  • [7] Disentangling neural cell diversity using single-cell transcriptomics
    Poulin, Jean-Francois
    Tasic, Bosiljka
    Hjerling-Leffler, Jens
    Trimarchi, Jeffrey M.
    Awatramani, Rajeshwar
    NATURE NEUROSCIENCE, 2016, 19 (09) : 1131 - 1141
  • [8] Single-cell transcriptomics unveils xylem cell development and evolution
    Tung, Chia-Chun
    Kuo, Shang-Che
    Yang, Chia-Ling
    Yu, Jhong-He
    Huang, Chia-En
    Liou, Pin-Chien
    Sun, Ying-Hsuan
    Shuai, Peng
    Su, Jung-Chen
    Ku, Chuan
    Lin, Ying-Chung Jimmy
    GENOME BIOLOGY, 2023, 24 (01)
  • [9] Longitudinal single-cell transcriptomics reveals distinct patterns of recurrence in acute myeloid leukemia
    Zhai, Yanan
    Singh, Prashant
    Dolnik, Anna
    Brazda, Peter
    Atlasy, Nader
    del Gaudio, Nunzio
    Dohner, Konstanze
    Dohner, Hartmut
    Minucci, Saverio
    Martens, Joost
    Altucci, Lucia
    Megchelenbrink, Wout
    Bullinger, Lars
    Stunnenberg, Hendrik G.
    MOLECULAR CANCER, 2022, 21 (01)
  • [10] Integrated single-cell and spatial transcriptomics reveals heterogeneity of fibroblast and pivotal genes in psoriasis
    He, Cong-cong
    Song, Tian-cong
    Qi, Rui-qun
    Gao, Xing-Hua
    SCIENTIFIC REPORTS, 2023, 13 (01):