Menopause, Estrogens, and Glucose Homeostasis in Women

被引：21

作者：

Mauvais-Jarvis, Franck ^{[1
]}

机构：

[1] Tulane Univ, Dept Med, Sect Endocrinol & Metab, Hlth Sci Ctr,Sch Med, New Orleans, LA 70118 USA

来源：

SEX AND GENDER FACTORS AFFECTING METABOLIC HOMEOSTASIS, DIABETES AND OBESITY | 2017年 / 1043卷

基金：

美国国家卫生研究院;

关键词：

POSTMENOPAUSAL HORMONE-THERAPY; CONJUGATED EQUINE ESTROGEN; REPLACEMENT THERAPY; INSULIN SENSITIVITY; TRANSDERMAL; 17-BETA-ESTRADIOL; PLASMA-LIPIDS; DOUBLE-BLIND; ELIMINATION; SECRETION; LIPOPROTEINS;

D O I：

10.1007/978-3-319-70178-3_11

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Randomized trials suggest that menopausal hormone therapy (MHT) prevents type 2 diabetes. Still, the mechanisms of these antidiabetic effects are a matter of controversy. This chapter provides an analysis of epidemiological and clinical evidence and proposes a mechanism for the effect of menopause and MHT on type 2 diabetes development and prevention. It discusses the beneficial role of estradiol on glucose homeostasis that is lost at menopause and improved by MHT, which delays type 2 diabetes. This chapter aims to reconcile differences among studies of the effect of menopause and MHT formulations on type 2 diabetes and argues that discrepancies arise from physiological differences in methods used to assess glucose homeostasis.

引用

收藏

页码：217 / 225

页数：9

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