COVID-19 disease and immune dysregulation

被引：36
|
作者：
Davitt, Ethan [1 ]
Davitt, Colin [2 ]
Mazer, Monty B. [3 ,5 ]
Areti, Sathya S. [4 ]
Hotchkiss, Richard S. [1 ,2 ]
Remy, Kenneth E. [2 ,3 ,4 ,5 ,6 ]
机构：
[1] Washington Univ, Sch Med, St Louis, MO USA
[2] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO USA
[3] Univ Hosp Cleveland, Dept Pediat, Cleveland, OH USA
[4] Univ Hosp Cleveland, Dept Internal Med, Cleveland, OH USA
[5] Case Western Reserve Univ, Sch Med, Cleveland, OH USA
[6] Case Western Reserve Univ, Univ Hosp Cleveland, Sch Med, Dept Internal Med, 11100 Euclid Ave, Cleveland, OH 44106 USA
来源：
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2022年 / 35卷 / 03期
基金：
美国国家卫生研究院;
关键词：
COVID-19; SARS-CoV-2; Immunology; Host immune response; Innate; Adaptive; COMPLEMENT ACTIVATION; INFECTION;
D O I：
10.1016/j.beha.2022.101401
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The SARS-CoV-2 virus has complex and divergent immune alterations in differing hosts and over disease evolution. Much of the nuanced COVID-19 disease immune dysregulation was originally dominated by innate cytokine changes, which has since been replaced with a more complex picture of innate and adaptive changes characterized by simultaneous hyperinflammatory and immunosuppressive phenomena in effector cells. These intricacies are summarized in this review as well as potential relevance from acute infection to a multisystem inflammatory syndrome commonly seen in children. Additional consideration is made for the influence of variant to variant host cellular changes and the impact of potential vaccination upon these phenotypes. Finally, therapeutic benefit for immune alterations are discussed.
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页数：8
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