Intraoperative positive end-expiratory pressure evaluation using the intratidal compliance-volume profile

被引:37
作者
Wirth, S. [1 ]
Baur, M. [1 ]
Spaeth, J. [1 ]
Guttmann, J. [1 ]
Schumann, S. [1 ]
机构
[1] Univ Med Ctr Freiburg, Dept Anesthesiol & Intens Care Med, D-79106 Freiburg, Germany
关键词
compliance-volume curve; elective surgery; lung compliance mechanical ventilation; respiratory system mechanics; MORBIDLY OBESE-PATIENTS; POSTOPERATIVE PULMONARY COMPLICATIONS; RESPIRATORY SYSTEM MECHANICS; ABDOMINAL-SURGERY; IMPEDANCE TOMOGRAPHY; GENERAL-ANESTHESIA; SLICE METHOD; VENTILATION; ATELECTASIS; LUNG;
D O I
10.1093/bja/aeu385
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Background. Lung-protective mechanical ventilation during general surgery including the application of PEEP can reduce postoperative pulmonary complications. In a prospective clinical observation study, we evaluated volume-dependent respiratory system compliance in adult patients undergoing ear-nose-throat surgery with ventilation settings chosen empirically by the attending anaesthetist. Methods. In 40 patients, we measured the respiratory variables during intraoperative mechanical ventilation. All measurements were subdivided into 5 min intervals. Dynamic compliance (C-RS) and the intratidal volume-dependent C-RS curve was calculated for each interval and classified into one of the six specific compliance profiles indicating intratidal recruitment/derecruitment, overdistension or all. We retrospectively compared the occurrences of the respective compliance profiles at PEEP levels of 5 cm H2O and at higher levels. Results. The attending anaesthetists set the PEEP level initially to 5 cm H2O in 29 patients (83%), to 7 cm H2O in 5 patients (14%), and to 8 cm H2O in 2 patients (6%). Across all measurements the mean C-RS was 61 (11) ml cm H2O-1 (40-86 ml cm H2O-1) and decreased continuously during the procedure. At PEEP of 5 cm H2O the compliance profile indicating strong intratidal recruitment/derecruitment occurred more often (18.6%) compared with higher PEEP levels (5.5%, P<0.01). Overdistension was practically never observed. Conclusions. In most patients, a PEEP of 5 cm H2O during intraoperative mechanical ventilation is too low to prevent intratidal recruitment/derecruitment. The analysis of the intratidal compliance profile provides the rationale to individually titrate a PEEP level that stabilizes the alveolar recruitment status of the lung during intraoperative mechanical ventilation.
引用
收藏
页码:483 / 490
页数:8
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