Viral approaches to study the mammalian brain: Lineage tracing, circuit dissection and therapeutic applications

被引：6
作者：
Cong, Wei [1 ,2 ]
Shi, Yun [1 ,2 ]
Qi, Yanqing [1 ,2 ]
Wu, Jinyun [1 ,2 ]
Gong, Ling [1 ,2 ]
He, Miao [1 ,2 ]
机构：
[1] Fudan Univ, Zhongshan Hosp, State Key Lab Med Neurobiol, Dept Neurol, Shanghai, Peoples R China
[2] Fudan Univ, Zhongshan Hosp, MOE Frontiers Ctr Brain Sci, Inst Brain Sci, Shanghai, Peoples R China
来源：
JOURNAL OF NEUROSCIENCE METHODS | 2020年 / 335卷
基金：
中国国家自然科学基金;
关键词：
Virus; Gene delivery; Lineage tracing; Circuit mapping; Gene therapy; Cell type; VESICULAR STOMATITIS-VIRUS; GENE-THERAPY; ADENOASSOCIATED VIRUS; NERVOUS-SYSTEM; TRANSGENE EXPRESSION; GABAERGIC NEURONS; CORTICAL-NEURONS; CELL LINEAGE; VECTOR; DELIVERY;
D O I：
10.1016/j.jneumeth.2020.108629
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Viral vectors are widely used to study the development, function and pathology of neural circuits in the mammalian brain. Their flexible payloads with customizable choices of tool genes allow versatile applications ranging from lineage tracing, circuit mapping and functional interrogation, to translational and therapeutic applications. Different applications have distinct technological requirements, therefore, often utilize different types of virus. This review introduces the most commonly used viruses for these applications and some recent advances in improving the resolution and throughput of lineage tracing, the efficacy and selectivity of circuit tracing and the specificity of cell type targeting.
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页数：11
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