The Role of Gut Microbiota in Gastrointestinal Tract Cancers

被引：13
作者：
Grochowska, Marta [1 ]
Perlejewski, Karol [1 ]
Laskus, Tomasz [2 ]
Radkowski, Marek [1 ]
机构：
[1] Med Univ Warsaw, Dept Immunopathol Infect & Parasit Dis, Warsaw, Poland
[2] Med Univ Warsaw, Dept Adult Infect Dis, Warsaw, Poland
来源：
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2022年 / 70卷 / 01期
关键词：
Microbiota; Gastrointestinal tract; Cancer; Oral; Esophageal; Gastric; Pancreatic; Hepatocellular; Colorectal; HELICOBACTER-PYLORI ERADICATION; FACTOR-KAPPA-B; FUSOBACTERIUM-NUCLEATUM; COLORECTAL-CANCER; ESOPHAGEAL CANCER; GASTRIC-CANCER; PANCREATIC-CANCER; BACTERIA PRESENT; LIVER-CANCER; COLON-CANCER;
D O I：
10.1007/s00005-021-00641-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Disturbances in gastrointestinal (GI) microbiota could play a significant role in the development of GI cancers, but the underlying mechanisms remain largely unclear. While some bacteria seem to facilitate carcinogenesis, others appear to be protective. So far only one bacterium (Helicobacter pylori) has been classified by the International Agency for Cancer Research as carcinogenic in humans but many other are the subject of intense research. Most studies on the role of microbiota in GI tract oncogenesis focus on pancreatic and colorectal cancers with the following three species: Helicobacter pylori, Escherichia coli, and Porphyromonas gingivalis as likely causative factors. This review summarizes the role of bacteria in GI tract oncogenesis.
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页数：14
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