Effect of maternal pre-pregnancy BMI and weekly gestational weight gain on the development of infants

被引：17

作者：

Li, Chao ^{[1
]}

Zeng, Lingxia ^{[1
]}

Wang, Duolao ^{[2
]}

Dang, Shaonong ^{[1
]}

Chen, Tao ^{[2
]}

Watson, Victoria ^{[2
]}

Yan, Hong ^{[1
,3
,4
,5
]}

机构：

[1] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Xian, Shaanxi, Peoples R China

[2] Univ Liverpool Liverpool Sch Trop Med, Dept Clin Sci, Pembroke Pl, Liverpool, Merseyside, England

[3] Nutr & Food Safety Engn Res Ctr Shaanxi Prov, Xian, Shaanxi, Peoples R China

[4] Xi An Jiao Tong Univ, Key Lab Environm & Genes Related Dis, Xian, Shaanxi, Peoples R China

[5] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, 76 West Yanta Rd,POB 46, Xian 710061, Shaanxi, Peoples R China

来源：

NUTRITION JOURNAL | 2019年 / 18卷 / 1期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Maternal pre-pregnancy BMI; Weekly gestational weight gain; Development of infants; BODY-MASS INDEX; PRENATAL MICRONUTRIENT SUPPLEMENTATION; SCHOOL-AGED CHILDREN; ADOLESCENCE FINDINGS; MULTIPLE IMPUTATION; ASSOCIATIONS; GROWTH; MALNUTRITION; CHILDHOOD; PREGNANCY;

D O I：

10.1186/s12937-019-0432-8

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

ObjectiveThe aim of the present study is to identify the average effect across different time points and to specify the time effects of maternal pre-pregnancy BMI and weekly gestational weight gain on the mental development and physical growth of infants.MethodsThe present cohort study used a repeated measures study design that began in 2004 with follow up at 3, 6, 12, 18, and 24months of age. The participants were a subset from a controlled, cluster-randomized, double-blind trial. Bayley Scales of Infant Development (BSID) were used to estimate the mental development of infants. A generalized estimating equation linear model was used to estimate the effects of maternal BMI and weight gain.ResultsThe average effect of maternal BMI and weight gain on the weight for age Z scores (WAZ), length for age Z scores (LAZ) and mental development index (MDI) across the different time points of infants was significant. In addition, the maternal BMI and weight gain were positively and significantly associated with the WAZ and LAZ in infants of different ages. However, the effect of weekly gestational weight gain was significant only during the earlier period of life (3months, Coefficient: 11.15, 95%CI: 4.89-17.41).ConclusionsOur results indicate positive effects of pre-pregnancy and prenatal nutrition on the physical growth of infants. Weekly gestational weight gain of the pregnant women had a positive effect on the mental development of the infants, but this effect appears to decline over time.

引用

页数：12