PTPN2 in the Immunity and Tumor Immunotherapy: A Concise Review

被引：25

作者：

Song, Jiachun ^{[1
]}

Lan, Jinxin ^{[1
]}

Tang, Jiaping ^{[1
]}

Luo, Na ^{[1
]}

机构：

[1] Nankai Univ, Sch Med, Dept Anat & Histol, Tianjin 300071, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 17期

基金：

中国国家自然科学基金;

关键词：

PTPN2; inflammation; tumor immunotherapy; PROTEIN-TYROSINE-PHOSPHATASE; BLOOD-BRAIN-BARRIER; NEGATIVE REGULATOR; ACTIVATION; IDENTIFICATION; TCPTP; PROLIFERATION; FAMILY; DIFFERENTIATION; LOCALIZATION;

D O I：

10.3390/ijms231710025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PTPN2 (protein tyrosine phosphatase non-receptor 2), also called TCPTP (T cell protein tyrosine phosphatase), is a member of the PTP family signaling proteins. Phosphotyrosine-based signaling of this non-transmembrane protein is essential for regulating cell growth, development, differentiation, survival, and migration. In particular, PTPN2 received researchers' attention when Manguso et al. identified PTPN2 as a cancer immunotherapy target using in vivo CRISPR library screening. In this review, we attempt to summarize the important functions of PTPN2 in terms of its structural and functional properties, inflammatory reactions, immunomodulatory properties, and tumor immunity. PTPN2 exerts synergistic anti-inflammatory effects in various inflammatory cells and regulates the developmental differentiation of immune cells. The diversity of PTPN2 effects in different types of tumors makes it a potential target for tumor immunotherapy.

引用

页数：14

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