Hepatitis C Virus Infection in the Older Patient

被引：45

作者：

Reid, Michael ^{[1
]}

Price, Jennifer C. ^{[1
]}

Tien, Phyllis C. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Med, 513 Parnassus Ave, San Francisco, CA 94122 USA

[2] Dept Veteran Affairs Med Ctr, Med Serv, San Francisco, CA 94121 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 2017年 / 31卷 / 04期

关键词：

HCV; Aging; Comorbidity; Inflammation; CHRONIC KIDNEY-DISEASE; UNITED-STATES; INSULIN-RESISTANCE; ELDERLY-PATIENTS; COGNITIVE FUNCTION; PERSONS BORN; RISK; PREVALENCE; AGE; HCV;

D O I：

10.1016/j.idc.2017.07.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Hepatitis C virus (HCV) is the most common blood-borne infection in the United States and is of concern in older adults. HCV infection is associated with not only hepatic but also extrahepatic comorbidities common to the aging patient, including diabetes, kidney and cardiovascular diseases, and neurocognitive impairment. The effect of direct-acting antiviral agents to treat HCV on these outcomes is limited. This article summarizes the literature regarding the epidemiology and natural history of HCV infection; the impact of age on clinical outcomes in HCV-infected persons; and current knowledge regarding safety and efficacy of HCV treatment regimens in the older patient.

引用

页码：827 / +

页数：14

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