Distribution of androgen receptor mRNA in the prepubertal male and female mouse brain

被引:22
|
作者
Cara, Alexandra L. [1 ]
Henson, Emily L. [1 ]
Beekly, Bethany G. [2 ]
Elias, Carol F. [1 ,2 ,3 ]
机构
[1] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Neurosci Grad Program, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Obstet & Gynaecol, Ann Arbor, MI 48109 USA
关键词
gonadal steroids; postnatal development; puberty; sex differences; CA1 HIPPOCAMPAL SUBFIELD; DENDRITIC SPINE DENSITY; ESTROGEN-RECEPTOR; SEX-DIFFERENCES; STRIA TERMINALIS; RIBONUCLEIC-ACID; MOTOR NUCLEI; MICE LACKING; BED NUCLEUS; ADULT MALE;
D O I
10.1111/jne.13063
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Androgens are steroid hormones that play a critical role in brain development and sexual maturation by acting upon both androgen receptors (AR) and estrogen receptors (ER alpha/beta) after aromatization. The contribution of estrogens from aromatized androgens in brain development and the central regulation of metabolism, reproduction, and behavior is well defined, but the role of androgens acting on AR has been unappreciated. Here, we map the sex specific expression of Ar in the adult and developing mouse brain. Postnatal days (PND) 12 and 21 were used to target a critical window of prepubertal development. Consistent with previous literature in adults, sex-specific differences in Ar expression were most profound in the bed nucleus of the stria terminalis (BST), medial amygdala (MEA) and medial preoptic area (MPO). Ar expression was also high in these areas at PND 12 and 21 in both sexes. In addition, we describe extra-hypothalamic and extra-limbic areas that show moderate, consistent and similar Ar expression in both sexes at both prepubertal time points. Briefly, Ar expression was observed in olfactory areas of the cerebral cortex, the hippocampus, several thalamic nuclei, and cranial nerve nuclei involved in autonomic sensory and motor function. To further characterize forebrain populations of Ar expressing neurons and determine whether they also coexpress estrogen receptors, we examined expression of Ar, Esr1 and Esr2 in prepubertal mice in selected nuclei. We found populations of neurons in the BST, MEA and MPO that coexpress Ar, but not Esr1 or Esr2, whereas others express a combination of the three receptors. Our findings indicate that various brain areas express Ar during prepubertal development and may play an important role in female neuronal development and physiology.
引用
收藏
页数:18
相关论文
共 50 条
  • [31] Neuroanatomical distribution of Huntingtin-associated protein 1-mRNA in the male mouse brain
    Fujinaga, R
    Kawano, J
    Matsuzaki, Y
    Kamei, K
    Yanai, A
    Sheng, ZJ
    Tanaka, M
    Nakahama, KI
    Nagano, M
    Shinoda, K
    JOURNAL OF COMPARATIVE NEUROLOGY, 2004, 478 (01) : 88 - 109
  • [34] Breeding status affects the expression of androgen and progesterone receptor mRNA in the brain of male Damaraland mole-rats
    Voigt, C.
    Leitner, S.
    Bennett, N. C.
    JOURNAL OF ZOOLOGY, 2016, 298 (03) : 209 - 216
  • [35] Amplification of exons 4 and 5 of androgen receptor gene by testosterone in aged female mouse brain cortex
    M.K. Thakur
    A. Asaithambi
    Shibani Mukherjee
    Biogerontology, 2000, 1 : 329 - 334
  • [36] A competitive effect of androgen signaling on male mouse attraction to volatile female mouse odors
    Muroi, Y
    Ishii, T
    Komori, S
    Nishimura, M
    PHYSIOLOGY & BEHAVIOR, 2006, 87 (01) : 199 - 205
  • [37] Amplification of exons 4 and 5 of androgen receptor gene by testosterone in aged female mouse brain cortex
    Thakur, MK
    Asaithambi, A
    Mukherjee, S
    BIOGERONTOLOGY, 2000, 1 (04) : 329 - 334
  • [38] Distribution and differences of estrogen receptor beta immunoreactivity in the brain of adult male and female rats
    Zhang, JQ
    Cai, WQ
    Zhou, DS
    Su, BY
    BRAIN RESEARCH, 2002, 935 (1-2) : 73 - 80
  • [39] Distribution of aromatase, estrogen receptor, and androgen receptor mRNA in the forebrain of songbirds and nonsongbirds
    Metzdorf, R
    Gahr, M
    Fusani, L
    JOURNAL OF COMPARATIVE NEUROLOGY, 1999, 407 (01) : 115 - 129
  • [40] Hormonal Regulation of Steroid Receptor Coactivator-1 mRNA in the Male and Female Green Anole Brain
    Kerver, H. N.
    Wade, J.
    JOURNAL OF NEUROENDOCRINOLOGY, 2015, 27 (03) : 223 - 233