Asymmetric Aldol Reaction of Dichloroacetaldehyde Catalyzed by Diarylprolinol

被引：10
作者：
Hayashi, Yujiro [1 ]
Nakamura, Daichi [1 ]
Yasui, Yusuke [1 ]
Iwasaki, Kotaro [1 ]
Chiba, Hiroaki [1 ]
机构：
[1] Tohoku Univ, Grad Sch Sci, Dept Chem, Aoba Ku, 6-3 Aramaki Aza Aoba, Sendai, Miyagi 9808578, Japan
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2016年 / 358卷 / 14期
关键词：
aldol reaction; asymmetric synthesis; dichloroacetaldehyde; organocatalysts; DIPHENYLPROLINOL SILYL ETHER; ALDEHYDES; ORGANOCATALYSIS; CONSTRUCTION; CHEMISTRY;
D O I：
10.1002/adsc.201501111
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The asymmetric cross-aldol reaction of dichloroacetaldehyde with aldehyde pronucleophiles proceeds in the presence of a trifluoromethyl-substituted diarylprolinol to afford gamma,gamma-dichloro-beta-hydroxy aldehydes in good yield with excellent enantioselectivity. The obtained products are useful synthetic intermediates; they were successfully converted to form chiral alkynes and dichloroalkenes.
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收藏
页码：2345 / 2351
页数：7
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