Expression Pattern of Receptor Activator of NFκB (RANK) in a Series of Primary Solid Tumors and Related Bone Metastases

被引:96
|
作者
Santini, Daniele [2 ]
Perrone, Giuseppe [3 ]
Roato, Ilaria [4 ]
Godio, Laura [5 ]
Pantano, Francesco [2 ]
Grasso, Donatella [6 ,7 ]
Russo, Antonio [1 ]
Vincenzi, Bruno [2 ]
Fratto, Maria Elisabetta [2 ]
Sabbatini, Roberto [8 ]
Della Pepa, Chiara [2 ]
Porta, Camillo [6 ,7 ]
Del Conte, Alessandro [9 ]
Schiavon, Gaia [2 ]
Berruti, Alfredo [10 ]
Tomasino, Rosa Maria [11 ]
Papotti, Mauro [5 ]
Papapietro, Nicola [12 ]
Muda, Andrea Onetti [3 ]
Denaro, Vincenzo [12 ]
Tonini, Giuseppe [2 ]
机构
[1] Univ Palermo, Sect Med Oncol, Dept Surg & Oncol Sci, I-90127 Palermo, Italy
[2] Univ Campus Biomed, Dept Med Oncol, Rome, Italy
[3] Univ Campus Biomed, Dept Surg Pathol, Rome, Italy
[4] Cell Therapeut Inc, Milan, Italy
[5] Univ Turin, Dept Pathol, Turin, Italy
[6] Univ Pavia, Dept Med Oncol, I-27100 Pavia, Italy
[7] Policlin San Matteo, Ist Ricovero & Cura Carattere Sci, I-27100 Pavia, Italy
[8] Univ Modena & Reggio Emilia, Dept Med Oncol, Modena, Italy
[9] Osped Empoli, Dept Med Oncol, Empoli, Italy
[10] Univ San Luigi Orbassano, Azienda Osped, Dept Med Oncol, Turin, Italy
[11] Univ Palermo, Dept Pathol, I-90127 Palermo, Italy
[12] Univ Campus Biomed, Dept Orthoped, Rome, Italy
关键词
HUMAN PROSTATE-CANCER; OSTEOCLAST DIFFERENTIATION; OSTEOSARCOMA CELLS; LIGAND; RANKL/RANK/OPG; CARCINOMA; DENOSUMAB;
D O I
10.1002/jcp.22402
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Receptor activator of NF kappa B ligand (RANKL), RANK, and osteoprotegerin (OPG) represent the key regulators of bone metabolism both in normal and pathological conditions, including bone metastases. To our knowledge, no previous studies investigated and compared RANK expression in primary tumors and in bone metastases from the same patient. We retrospectively examined RANK expression by immunohistochemistry in 74 bone metastases tissues from solid tumors, mostly breast, colorectal, renal, lung, and prostate cancer. For 40 cases, tissue from the corresponding primary tumor was also analyzed. Sixty-six (89%) of the 74 bone metastases were RANK-positive and, among these, 40 (59.5%) showed more than 50% of positive tumor cells. The median percentage of RANK-positive cells was 60% in primary tumors and metastases, without any statistically significant difference between the two groups (P = 0.194). The same percentage was obtained by considering only cases with availability of samples both from primary and metastasis. Our study shows that RANK is expressed by solid tumors, with high concordance between bone metastasis and corresponding primary tumor. These data highlight the central role of RANK/RANKL/OPG pathway as potential therapeutic target not only in bone metastasis management, but also in the adjuvant setting. J. Cell. Physiol. J. Cell. Physiol. 226: 780-784, 2011. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码:780 / 784
页数:5
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