Reviving the exosome

被引：18
作者：
Jensen, TH [1 ]
Moore, C
机构：
[1] Aarhus Univ, Dept Biol Mol, DK-8000 Aarhus, Denmark
[2] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA
来源：
CELL | 2005年 / 121卷 / 05期
关键词：
D O I：
10.1016/j.cell.2005.05.018
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et al. (2005) help to solve this riddle by characterizing a new RNA decay-activating complex containing a poly(A) polymerase. In addition, they identify new unconventional RNA polymerase 11 transcription units.
引用
收藏
页码：660 / 662
页数：3
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